catalog number :
MBS530435
products full name :
Ubiquitin antibody
products short name :
Ubiquitin
products name syn :
Monoclonal Ubiquitin; Anti-Ubiquitin; UB
other names :
ubiquitin; Ubiquitin-40S ribosomal protein S27a; ubiquitin-40S ribosomal protein S27a; ribosomal protein S27a; Ubiquitin carboxyl extension protein 80
other gene names :
RPS27A; RPS27A; UBC; S27A; CEP80; UBA80; HEL112; UBCEP1; UBCEP80; UBA80; UBCEP1
uniprot entry name :
RS27A_HUMAN
reactivity :
To be determined by end-user
form :
Supplied in PBS with 50% glycerol.
concentration :
1.0 mg/ml
storage stability :
Aliquot and store at -20 degree C. Avoid repeated Freeze/Thaw cycles
tested application :
Western Blot (WB)
other info1 :
Biological Significance: Ubiquitin is a polypeptide of 76 amino acid residues, and widely distributed protein in eukaryotic cells. This protein is also highly conserved among eukaryotic cells. There are several reports showed that intracellular abnormal and short-lived proteins are degraded through an ubiquitin dependent proteolytic pathway. In the ubiquitin dependent pathway, a target protein is tagged with multi-ubiquitin molecules.
other info2 :
Immunogen: Ubiquitin antibody was raised in mouse using purified bovine erythrocyte ubiquitin as the immunogen.
products categories :
Protein Modification & Stress Response
products description :
Mouse monoclonal Ubiquitin antibody
ncbi acc num :
CAA44911.1
ncbi mol weight :
17,965 Da
ncbi pathways :
APC-Cdc20 Mediated Degradation Of Nek2A Pathway 1127551!!APC/C-mediated Degradation Of Cell Cycle Proteins Pathway 105825!!APC/C:Cdc20 Mediated Degradation Of Cyclin B Pathway 105832!!APC/C:Cdc20 Mediated Degradation Of Securin Pathway 105833!!APC/C:Cdc20 Mediated Degradation Of Mitotic Proteins Pathway 105831!!APC/C:Cdh1 Mediated Degradation Of Cdc20 And Other APC/C:Cdh1 Targeted Proteins In Late Mitosis/early G1 Pathway 105835!!APC:Cdc20 Mediated Degradation Of Cell Cycle Proteins Prior To Satisfation Of The Cell Cycle Checkpoint Pathway 1127549!!AUF1 (hnRNP D0) Destabilizes MRNA Pathway 187212!!Activated NOTCH1 Transmits Signal To The Nucleus Pathway 576270!!Activated NOTCH1 Transmits Signal To The Nucleus Pathway 1168352
ncbi summary :
Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]