protein

IARS protein (His tag)

MBS5304271

0.1 mg

275 USD

Recombinant Protein

IARS protein (His tag)

[IARS]

[Isoleucyl-TRNA Synthetase protein; IleRS protein; OJ protein]

[IARS protein; Isoleucine--tRNA ligase, cytoplasmic; isoleucine--tRNA ligase, cytoplasmic; isoleucyl-tRNA synthetase; Isoleucyl-tRNA synthetase; IRS; IleRS]

[IARS]

[IARS; IARS; IRS; ILRS; IARS1; ILERS; PRO0785; IRS; IleRS]

SYIC_HUMAN

Human

1055

1-1262 aa

> 75% pure. Purified using proprietary chromatographic techniques

Liquid in 50mM Tris, pH 8.5 with 150 mM NaCI, 2mM MgCI 2 ,10% Glycerol, 1mM ,1 mM EDTA, and 2mM DTT.

0.8 mg/mL

Ships on dry ice. Upon receipt store at -70°C.

SDS-PAGE

Protein Type: Recombinant. Biological Significance: IARSbelongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis.

Expression System: Baculovirus. Tag/Conjugate: His-GST tag. Expression: IARS is expressed in response to inflammation and DNA damage. IARS is expressed in the membrane and cytoplasm of the majority of mammalian cells. Implications in Disease: Diseases associates with IARS include polymyositis, a type of chronic inflammation of the muscles (inflammatory myophaty) related to dermatomyositis and inclusion body myositis and inclusion body myositis,and dermatomyositis, a connective-tissue disease related to polymyositis (PM) that is characterized by inflammation of the muscles and the skin. Post-transactional Modifications: Ubiquination occurs at Lys410, Lys450, Lys868, Lys917 and Lys1051.

Proteases, Inhibitors, Conjugated Proteins

Purified recombinant IARS (OJ) protein (His tag)

41351160

AAH65552.1

148 kDa

Aminoacyl-tRNA Biosynthesis Pathway (83030); Aminoacyl-tRNA Biosynthesis Pathway (424); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (413439); Aminoacyl-tRNA Biosynthesis, Eukaryotes Pathway (468360); Cytosolic TRNA Aminoacylation Pathway (105981); Gene Expression Pathway (105937); TRNA Aminoacylation Pathway (105980)

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Alternatively spliced transcript variants have been found. [provided by RefSeq, Nov 2012]

IARS: Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAS, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. Isoleucine-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family and has been identified as a target of autoantibodies in the autoimmune disease polymyositis/dermatomyositis. Two alternatively spliced variants have been isolated that represent alternate 5 UTRs. [provided by RefSeq, Jul 2008]. Protein type: Translation; EC 6.1.1.5; Ligase; Amino Acid Metabolism - valine, leucine and isoleucine biosynthesis. Chromosomal Location of Human Ortholog: 9q21. Cellular Component: nucleoplasm; membrane; cytoplasm; cytosol. Molecular Function: protein binding; ATP binding; isoleucine-tRNA ligase activity. Biological Process: osteoblast differentiation; isoleucyl-tRNA aminoacylation; tRNA aminoacylation for protein translation; regulation of translational fidelity; gene expression

0.1 mg

275 USD

1 mg

2180