catalog number :
MBS5304234
products type :
Recombinant Protein
products full name :
Calbindin protein
products short name :
[Calbindin]
products name syn :
[CAB27 protein; CALB 1 protein; CALB protein; CALB1 protein; Calbindin 1 28kDa protein; Calbindin D28 protein; D 28K protein; D28K protein; Vitamin D dependent calcium binding protein protein; Vitamin D dependent calcium binding protein avian type protein; Vitamin D dependent calcium binding protein avian-type protein; Vitamin D-dependent calcium-binding protein protein]
other names :
[calbindin; Calbindin; calbindin; calbindin 1, 28kDa; Calbindin D28; D-28K; Vitamin D-dependent calcium-binding protein, avian-type]
other gene names :
[CALB1; CALB1; CALB; D-28K; CAB27]
uniprot entry name :
CALB1_HUMAN
purity :
> 95% by SDS-PAGE
form :
Supplied in lyophilized form from 20mM Tris, pH 8.0 / 10mM NaCl
concentration :
200ug, lyophilized
storage stability :
Ships refrigerated or frozen. Upon receipt store at -20 degree C. After reconstiution store at -80 degree C. Avoid repeated freeze-thaw cycles.
tested application :
Western Blot (WB)
image1 heading :
Western Blot (WB)
other info1 :
Protein Type: Recombinant. Biological Significance: Calbindin refers to several calcium-binding proteins. They were originally described as vitamin D-dependent calcium-binding proteins in the intestine and kidney in the chick and mammals. They are now classified in different sub-families as they differ in the number of Ca2+ binding EF-hand sites. Biohazard: Use standard laboratory procedures when handling this product.
other info2 :
Expression System: E Coli
products categories :
Protein Modification & Stress Response
products description :
Purified recombinant Calbindin protein
ncbi acc num :
NP_004920.1
ncbi gb acc num :
NM_004929.3
ncbi pathways :
Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276)
ncbi summary :
The protein encoded by this gene is a member of the calcium-binding protein superfamily that includes calmodulin and troponin C. Originally described as a 27 kDa protein, it is now known to be a 28 kDa protein. It contains four active calcium-binding domains, and has two modified domains that are thought to have lost their calcium binding capability. This protein is thought to buffer entry of calcium upon stimulation of glutamate receptors. Depletion of this protein was noted in patients with Huntington disease. [provided by RefSeq, Jan 2015]
uniprot summary :
CALB1: Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3 ,5 -cyclic nucleotide phosphodiesterase. Interacts with RANBP9. Belongs to the calbindin family. Protein type: Calcium-binding. Chromosomal Location of Human Ortholog: 8q21.3. Cellular Component: cell soma; axon; dendrite; synapse; nucleus; cytosol. Molecular Function: vitamin D binding; protein binding; zinc ion binding; calcium ion binding. Biological Process: cytosolic calcium ion homeostasis; long-term memory; short-term memory; regulation of synaptic plasticity; locomotory behavior