antibody

Calmodulin antibody

MBS530363

0.2 ml

605 USD

monoclonal

mouse

nonconjugated

6D4

human, chicken, cow

western blot, ELISA, immunocytochemistry, enzyme immunoassay

Antibody

Calmodulin antibody

Calmodulin

Monoclonal Calmodulin; Anti-Calmodulin

calmodulin isoform 2; Calmodulin; calmodulin; calmodulin 2 (phosphorylase kinase, delta)

CALM2; CALM1; caM; PHKD; CAMII; LQT15; PHKD2; CALM; CAM; CAM1; CaM

CALM_HUMAN

Monoclonal

IgG1

6D4

Mouse

Bovine, Chicken, Chlamydomonas, Dictyostellium, Rat

149

Dictyostelium discoideum

PBS-diluted ascites containing 0.05% NaN3.

1.0 mg/ml

Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

ELISA (EIA), Immunocytochemistry (ICC), Western Blot (WB)

ICC: 1:100. WB: 1:2,000

Biological Significance: Calmodulin is a small, highly conserved calcium binding protein found in all eukaryotic cells. With the capacity to bind up to four calcium ions, this 17 kDa protein acts as an important intracellular receptor for regulatory calcium signals.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Calmodulin antibody was raised in mouse using calmodulin purified from Dictyostelium discoideum as the immunogen.

Cell Biology

Mouse monoclonal Calmodulin antibody

4502549

NP_001734.1

NM_001743.4

P62158

16,838 Da

Activation Of Ca-permeable Kainate Receptor Pathway 161046!!Activation Of CaMK IV Pathway 161042!!Activation Of Kainate Receptors Upon Glutamate Binding Pathway 161043!!Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway 161033!!Adaptive Immune System Pathway 366160!!Adrenergic Signaling In Cardiomyocytes Pathway 908257!!Adrenergic Signaling In Cardiomyocytes Pathway 909696!!Alcoholism Pathway 585563!!Alcoholism Pathway 587116!!Alzheimer's Disease Pathway 83097

This gene is a member of the calmodulin gene family. There are three distinct calmodulin genes dispersed throughout the genome that encode the identical protein, but differ at the nucleotide level. Calmodulin is a calcium binding protein that plays a role in signaling pathways, cell cycle progression and proliferation. Several infants with severe forms of long-QT syndrome (LQTS) who displayed life-threatening ventricular arrhythmias together with delayed neurodevelopment and epilepsy were found to have mutations in either this gene or another member of the calmodulin gene family (PMID:23388215). Mutations in this gene have also been identified in patients with less severe forms of LQTS (PMID:24917665), while mutations in another calmodulin gene family member have been associated with catecholaminergic polymorphic ventricular tachycardia (CPVT)(PMID:23040497), a rare disorder thought to be the cause of a significant fraction of sudden cardiac deaths in young individuals. Pseudogenes of this gene are found on chromosomes 10, 13, and 17. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2015]

0.2 ml

605 USD