Desmoglein 1 antibody | MyBioSource MBS530355 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Desmoglein 1 antibody

catalog :

MBS530355

quantity :

5 mL

price :

395 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

Dsg1-P23

reactivity :

human

application :

western blot, immunohistochemistry, immunohistochemistry - paraffin section

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS530355

products type :

Antibody

products full name :

Desmoglein 1 antibody

products short name :

Desmoglein 1

products name syn :

Monoclonal Desmoglein 1; Anti-Desmoglein 1

other names :

desmoglein-1 preproprotein; Desmoglein-1; desmoglein-1; desmoglein 1; Cadherin family member 4; Desmosomal glycoprotein 1; DG1; DGI; Pemphigus foliaceus antigen

other gene names :

DSG1; DSG1; DG1; DSG; CDHF4; EPKHE; PPKS1; SPPK1; EPKHIA; CDHF4; DG1; DGI

uniprot entry name :

DSG1_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

Dsg1-P23

host :

Mouse

reactivity :

Human desmoglein 1

sequence length :

1049

purity :

Culture supernatant

form :

Hybridoma culture supernatant with 0.09% NaN3

concentration :

5.0ml per vial

storage stability :

Store at 4 degree C.

tested application :

Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)

other info1 :

Biological Significance: The desmogleins are a family of cadherins consisting of proteins DSG1, DSG2, DSG3, and DSG4. They play a role in the formation of desmosomes that join cells to one another. Desmoglein 1 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Desmoglein 1 antibody was raised in mouse using recombinant human polypeptide desmoglein 1, extracellular part EII, EIII and EIV as the immunogen.

products categories :

Cell Biology

products description :

Mouse monoclonal Desmoglein 1 antibody

ncbi gi num :

119703744

ncbi acc num :

NP_001933.2

ncbi gb acc num :

NM_001942.2

uniprot acc num :

Q02413

ncbi mol weight :

42,619 Da

ncbi pathways :

Apoptosis Pathway (105648); Apoptotic Cleavage Of Cell Adhesion Proteins Pathway (105680); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); Programmed Cell Death Pathway (1127510); Staphylococcus Aureus Infection Pathway (172846); Staphylococcus Aureus Infection Pathway (171867)

ncbi summary :

This gene encodes a member of the desmoglein protein subfamily. Desmogleins, along with desmocollins, are cadherin-like transmembrane glycoproteins that are major components of the desmosome. Desmosomes are cell-cell junctions that help resist shearing forces and are found in high concentrations in cells subject to mechanical stress. This gene is found in a cluster with other desmoglein family members on chromosome 18. The encoded protein has been identified as a target of auto-antibodies in the autoimmune skin blistering disease pemphigus foliaceus. Disruption of this gene has also been associated with the skin diseases palmoplantar keratoderma and erythroderma. [provided by RefSeq, Feb 2015]

uniprot summary :

DSG1: Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Defects in DSG1 are the cause of palmoplantar keratoderma striate type 1 (SPPK1); also known as keratosis palmoplantaris striata I. SPPK1 is a dermatoligical disorder characterized by thickening of the skin on the palms and soles, and longitudinal hyperkeratotic lesions on the palms, running the length of each finger. Protein type: Cell adhesion; Membrane protein, integral. Chromosomal Location of Human Ortholog: 18q12.1. Cellular Component: desmosome; internal side of plasma membrane; apical plasma membrane; plasma membrane; integral to membrane; intercellular junction; cytosol; lateral plasma membrane. Molecular Function: toxin binding; gamma-catenin binding; calcium ion binding. Biological Process: intercellular junction assembly; cell-cell adhesion; maternal process involved in pregnancy; protein stabilization; apoptosis; calcium-dependent cell-cell adhesion; response to progesterone stimulus; homophilic cell adhesion; cell structure disassembly during apoptosis. Disease: Palmoplantar Keratoderma I, Striate, Focal, Or Diffuse; Erythroderma, Congenital, With Palmoplantar Keratoderma, Hypotrichosis, And Hyper-ige

size1 :

5 mL

price1 :

395 USD

more info or order :

MyBioSource product webpage