catalog number :
MBS530354
products full name :
NSE antibody
products short name :
NSE
products name syn :
Monoclonal NSE; Anti-NSE; Neuron Specific Enolase; Neuron specific enolase; Enolase2; Enolase 2 gamma neuronal; Neural enolase; Enolase 2; gamma enolase; Anti NSE; Neuron specific gamma enolase; gamma-enolase; NSE
other names :
neuron-specific enolase; Gamma-enolase; gamma-enolase; enolase 2, gamma, neuronal; 2-phospho-D-glycerate hydro-lyase; Enolase 2; Neural enolase; Neuron-specific enolase; NSE
other gene names :
Eno2; Eno2; NSE; RNEN3; Eno-2; NSE
uniprot entry name :
ENOG_RAT
purity :
NSE antibody was purified by chromatography on protein G Sepharose.
form :
Chromatographically purified from mouse ascites and supplied in PBS, pH 7.4, with 0.1 % NaN3.
storage stability :
Store at 4 degree C.
tested application :
Immunohistochemistry (IHC) Formalin/Paraffin, Western Blot (WB)
other info1 :
Biological Significance: Neuron specific enolase (NSE), is an enzyme that in humans is encoded by the ENO2 gene. NSE is a phosphopyruvate hydratase. NSE is produced by small cell carcinomas which are neuroendocrine in origin. NSE is therefore a useful tumor marker for lung cancer patients.
other info2 :
Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: NSE antibody was raised in mouse using NSE from the human brain as the immunogen.
products categories :
Neuroscience
products description :
Mouse monoclonal NSE antibody
ncbi acc num :
AAB72088.1
ncbi mol weight :
47,141 Da
ncbi pathways :
Biosynthesis Of Amino Acids Pathway (791250); Biosynthesis Of Amino Acids Pathway (795174); Biosynthesis Of Antibiotics Pathway (1146234); Carbon Metabolism Pathway (816129); Carbon Metabolism Pathway (817567); Gluconeogenesis Pathway (1178045); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (434661); Gluconeogenesis, Oxaloacetate = Fructose-6P Pathway (468196); Glucose Metabolism Pathway (1178043); Glycolysis Pathway (1178044)
ncbi summary :
catalyzes the interconversion of 2-phosphoglycerate to phosphoenolpyruvate; may play a role in glycolysis [RGD, Feb 2006]
uniprot summary :
ENO2: an enzyme with 2-phospho-D-glycerate hydro-lyase activity. One of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. Protein type: Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lyase; EC 4.2.1.11. Cellular Component: extracellular space; neuron projection; phosphopyruvate hydratase complex; photoreceptor inner segment; cell soma; cytoplasm; perikaryon; intracellular; myelin sheath. Molecular Function: protein homodimerization activity; protein heterodimerization activity; magnesium ion binding; phosphopyruvate hydratase activity. Biological Process: response to drug; glycolysis; response to organic cyclic substance; response to estradiol stimulus; gluconeogenesis