catalog number :
MBS5303408
products full name :
Tenascin antibody
products short name :
[Tenascin]
products name syn :
[Polyclonal Tenascin; Anti-Tenascin; Cytotactin; GMEM; GP 150 225; Glioma associated extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin C; HXB]
other names :
[tenascin; Tenascin; tenascin; tenascin C; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; Tenascin-C; TN-C]
other gene names :
[TNC; TNC; GP; JI; TN; HXB; GMEM; TN-C; DFNA56; 150-225; HXB; TN; TN-C]
uniprot entry name :
TENA_HUMAN
reactivity :
Human. Others species not tested.
purity :
Tenascin antibody was purified by Ammonium Sulfate precipitation
form :
Liquid in 0.01M PBS, pH7.4, with 50% glycerol, and 0.03% Proclin 300.
storage stability :
Store at 4 shipping. Upon receipt store at -20 degree C to -80 degree C. Avoid repeat freeze/thaw cycles.
tested application :
ELISA (EIA)
other info1 :
Biological Significance: Tenascin is an extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration.
other info2 :
Immunogen: Tenascin antibody was raised in Rabbit using recombinant human Tenascin protein as the immunogen
products categories :
Neuroscience; Purified Polyclonal Antibodies
products description :
Rabbit polyclonal Tenascin antibody
ncbi acc num :
NP_002151.2
ncbi gb acc num :
NM_002160.3
ncbi pathways :
ECM Proteoglycans Pathway (833812); ECM-receptor Interaction Pathway (83068); ECM-receptor Interaction Pathway (479); Extracellular Matrix Organization Pathway (576262); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067); Focal Adhesion Pathway (478); Integrin Cell Surface Interactions Pathway (106110); MicroRNAs In Cancer Pathway (852705); MicroRNAs In Cancer Pathway (852928)
ncbi summary :
This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]
uniprot summary :
TNC: Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. Belongs to the tenascin family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 9q33. Cellular Component: extracellular matrix; extracellular space; focal adhesion; membrane; extracellular region; basement membrane. Molecular Function: syndecan binding. Biological Process: osteoblast differentiation; extracellular matrix organization and biogenesis; response to ethanol; wound healing; response to mechanical stimulus; positive regulation of cell proliferation; response to wounding; negative regulation of cell adhesion; cell adhesion; axon regeneration in the peripheral nervous system; neuromuscular junction development; odontogenesis of dentine-containing teeth. Disease: Deafness, Autosomal Dominant 56