catalog number :
MBS530337
products full name :
IL1b antibody
products short name :
IL1b
products name syn :
Monoclonal IL1b; Anti-IL1b; IL-1b; IL 1b; IL1 beta; IL1b; Interlekin 1 beta
other names :
interleukin-1 beta; Interleukin-1 beta; interleukin-1 beta; Lymphocyte proliferation-potentiating factor
products gene name :
IL1b
other gene names :
IL1B; IL1B; IL1-BETA; IL-1 beta
uniprot entry name :
IL1B_RABIT
form :
Supplied as a lyophilized powder. Reconstitute with PBS buffer.
storage stability :
Store at -20 degree C until reconstitution. Following reconstitution product may be stored at 4 degree C in the short term. For long term storage aliquot and freeze at -20 degree C. Avoid repeated freeze/thaw cycles.
tested application :
ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Western Blot (WB)
app notes :
ELISA: 2-8 ug/ml. IHC: 15 ug/ml. WB: 1 ug/ml,
other info1 :
Biological Significance: IL1 is a name that designates two pleiotropic cytokines, IL1 alpha (IL1F1) and IL1Beta (IL1F2), which are the products of distinct genes. IL1 alpha and IL1Beta are structurally related polypeptides that share approximately 21% amino acid (aa) identity in human. Both proteins are produced by a wide variety of cells in response to inflammatory agents, infections, or microbial endotoxins. While IL1 alpha and IL1Beta are regulated independently, they bind to the same receptor and exert identical biological effects. IL1 RI binds directly to IL1 alpha or IL1Beta and then associates with IL1R accessory protein (IL1R3/IL1R AcP) to form a highaffinity receptor complex that is competent for signal transduction.
other info2 :
Immunogen: IL1b antibody was raised in mouse using E Coli-derived recombinant human IL1 beta/IL1F2 as the immunogen.
products categories :
Cytokines & Growth Factors
products description :
Mouse monoclonal IL1b antibody
ncbi acc num :
NP_001075670.1
ncbi gb acc num :
NM_001082201.1
ncbi mol weight :
30,665 Da
ncbi pathways :
African Trypanosomiasis Pathway (1072959); African Trypanosomiasis Pathway (194323); Alzheimer's Disease Pathway (1072974); Alzheimer's Disease Pathway (509); Amoebiasis Pathway (1072961); Amoebiasis Pathway (167191); Apoptosis Pathway (1072857); Apoptosis Pathway (470); Chagas Disease (American Trypanosomiasis) Pathway (1072918); Chagas Disease (American Trypanosomiasis) Pathway (147795)