antibody

CKMB antibody

MBS530287

1 mg

560 USD

monoclonal

mouse

nonconjugated

M9910207

Antibody

CKMB antibody

CKMB

Monoclonal CKMB; Anti-CKMB; Creatine Kinase-MB Isoenzyme; CK-MB

creatine kinase M-type; Creatine kinase M-type; creatine kinase M-type; creatine kinase, muscle; Creatine kinase M chain; M-CK

CKMB

CKM; CKM; CKMM; M-CK; CKMM

KCRM_HUMAN

Monoclonal

IgG1 kappa

M9910207

Mouse

Human

381

10mM PBS, pH 7.3, with 0.05% sodium azide.

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Matched pair antibodies available for CKMB antibody: MBS535053 and MBS831787

Biological Significance: Creatine kinase (CK) is an enzyme expressed by various tissues and cell types. CK catalyses the conversion of creatine and consumes adenosine triphosphate (ATP) to create phosphocreatine and adenosine diphosphate (ADP). This CK enzyme reaction is reversible, such that also ATP can be generated from PCr and ADP. In the cells, the "cytosolic" CK enzymes consist of two subunits, which can be either B (brain type) or M (muscle type). There are, therefore, three different isoenzymes: CK-MM, CK-BB and CK-MB.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: CKMB antibody was raised in mouse using purified human CK-MB as the immunogen.

Cardiac Markers

Mouse monoclonal CKMB antibody

21536288

NP_001815.2

NM_001824.4

P06732

43,101 Da

Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Creatine Metabolism Pathway (106192); Creatine Pathway (413359); Creatine Pathway (468234); Metabolic Pathways (132956); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169); Regulation Of Retinoblastoma Protein Pathway (137916); Urea Cycle And Metabolism Of Amino Groups Pathway (198758)

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis and is an important serum marker for myocardial infarction. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in striated muscle as well as in other tissues, and as a heterodimer with a similar brain isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. [provided by RefSeq, Jul 2008]

CKM: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa. Belongs to the ATP:guanido phosphotransferase family. Protein type: Kinase, other; EC 2.7.3.2; Amino Acid Metabolism - arginine and proline. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: cytosol. Molecular Function: creatine kinase activity; ATP binding. Biological Process: phosphocreatine biosynthetic process; phosphorylation; creatine metabolic process

1 mg

560 USD