alpha 2 Macroglobulin antibody | MyBioSource MBS530238 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

alpha 2 Macroglobulin antibody

catalog :

MBS530238

quantity :

1 mg

price :

240 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

3127485

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS530238

products type :

Antibody

products full name :

alpha 2 Macroglobulin antibody

products short name :

alpha 2 Macroglobulin

products name syn :

Monoclonal alpha 2 Macroglobulin; Anti-alpha 2 Macroglobulin; alpha Macroglobulin -2; alpha 2 Macroglobulin; A2M; CPAMD5; S863 7; alpha Macroglobulin 2; alpha 2 M; FWP007; alpha 2M; DKFZp779B086

other names :

alpha-2-macroglobulin; Alpha-2-macroglobulin; alpha-2-macroglobulin; alpha-2-macroglobulin; C3 and PZP-like alpha-2-macroglobulin domain-containing protein 5

other gene names :

A2M; A2M; A2MD; CPAMD5; FWP007; S863-7; CPAMD5; Alpha-2-M

uniprot entry name :

A2MG_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

3127485

host :

Mouse

reactivity :

Human

sequence length :

1474

form :

Purified IgG from Mouse Ascites in PBS, pH7.9 with 0.02% NaN3.

concentration :

3.86 mg/ml

storage stability :

Store at 4 degree C for short term storage. Aliquot and store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

tested application :

User optimized

other info1 :

Biological Significance: A major serum protein found at concentrations of 240 mg per 100 ml in men and 290 mg per 100 ml in women. Multifunctional, it promotes growth of mammalian cells in culture, stimulates the regeneration of lymphocytes in irradiated mice, possesses a transport function for zinc and is a proteinase inhibitor that controls the clotting and fibrinolytic system. Clinically levels are increased in liver cirrhosis, nephrotic syndrome, diabetes, and severe burn cases.

other info2 :

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: Humam serum alpha-2-Macroglobulin.

products categories :

Proteases, Inhibitors, & Enzymes

products description :

Mouse monoclonal alpha 2 Macroglobulin antibody

ncbi gi num :

119608996

ncbi acc num :

EAW88590.1

uniprot acc num :

P01023

ncbi mol weight :

163,291 Da

ncbi pathways :

Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Degradation Of The Extracellular Matrix Pathway (576263); Extracellular Matrix Organization Pathway (576262); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057); HDL-mediated Lipid Transport Pathway (106158); Hemostasis Pathway (106028); IL6-mediated Signaling Events Pathway (137932); Intrinsic Pathway Of Fibrin Clot Formation (106059)

ncbi summary :

Alpha-2-macroglobulin is a protease inhibitor and cytokine transporter. It inhibits many proteases, including trypsin, thrombin and collagenase. A2M is implicated in Alzheimer disease (AD) due to its ability to mediate the clearance and degradation of A-beta, the major component of beta-amyloid deposits. [provided by RefSeq, Jul 2008]

uniprot summary :

A2M: Is able to inhibit all four classes of proteinases by a unique trapping mechanism. This protein has a peptide stretch, called the bait region which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. Protein type: Inhibitor; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 12p13.31. Cellular Component: extracellular region; cytosol. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; enzyme binding; protease binding; growth factor binding; interleukin-8 binding; interleukin-1 binding; calcium-dependent protein binding; tumor necrosis factor binding; receptor binding. Biological Process: negative regulation of complement activation, lectin pathway; extracellular matrix disassembly; platelet activation; regulation of small GTPase mediated signal transduction; extracellular matrix organization and biogenesis; platelet degranulation; small GTPase mediated signal transduction; stem cell differentiation; blood coagulation; blood coagulation, intrinsic pathway. Disease: Alzheimer Disease; Alpha-2-macroglobulin Deficiency

size1 :

1 mg

price1 :

240 USD

more info or order :

MyBioSource product webpage