antibody

Thyroid Peroxidase antibody

MBS530222

1 mg

550 USD

monoclonal

mouse

HRP

6H7

western blot, ELISA, enzyme immunoassay

Antibody

Thyroid Peroxidase antibody

Thyroid Peroxidase

Monoclonal Thyroid Peroxidase; Anti-Thyroid Peroxidase; Thyroid Peroxidase; TPX; MSA; TPO; Anti Thyroid Peroxidase

thyroid peroxidase, partial; Thyroid peroxidase; thyroid peroxidase; thyroid peroxidase

TPO; TPO; MSA; TPX; TDH2A; TPO

PERT_HUMAN

Monoclonal

IgG1

6H7

Mouse

To be determined by end-user

38

Human

Thyroid Peroxidase antibody was purified by chromatography on protein A Sepharose.

Protein A purified and supplied in PBS, pH 7.4, 0.1 % NaN3.

Store at 4 degree C.

ELISA (EIA), Western Blot (WB)

Biological Significance: Thyroid peroxidase (TPO) is an enzyme expressed mainly in the thyroid that liberates iodine for addition onto tyrosine residues on thyroglobulin for the production of thyroxine (T4) or triiodothyronine (T3), thyroid hormones. In humans, thyroperoxidase is encoded by the TPO gene.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Immunogen: Thyroid peroxidase antibody was raised in mouse using human thyroid peroxidase as the immunogen.

Proteases, Inhibitors, & Enzymes

Mouse monoclonal Thyroid Peroxidase antibody

4261820

AAD14120.1

92,063 Da

Amine-derived Hormones Pathway 160983!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Metabolic Pathways 132956!!Metabolism Pathway 477135!!Metabolism Of Amino Acids And Derivatives Pathway 106169!!Thyroid Hormone Biosynthesis, Tyrosine = Triiodothyronine/thyroxine Pathway 413358!!Thyroid Hormone Biosynthesis, Tyrosine = Triiodothyronine/thyroxine Pathway 468236!!Thyroid Hormone Synthesis Pathway 835410!!Thyroid Hormone Synthesis Pathway 839541

This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2011]

1 mg

550 USD