antibody

BMP4 antibody

MBS530217

0.1 mg

605 USD

monoclonal

mouse

nonconjugated

3H2

human, rat

western blot, ELISA, immunohistochemistry, immunocytochemistry, enzyme immunoassay

Antibody

BMP4 antibody

BMP4

Monoclonal BMP4; Anti-BMP4; BMP 4; BMP-2B; DVR4; Bone Morphogenetic Protein 4; BMP-4; BMP4

bone morphogenetic protein 4; Bone morphogenetic protein 4; bone morphogenetic protein 4; bone morphogenetic protein 4; Bone morphogenetic protein 2B; BMP-2B

BMP4

BMP4; BMP4; ZYME; BMP2B; OFC11; BMP2B1; MCOPS6; BMP2B; DVR4; BMP-4; BMP-2B

BMP4_HUMAN

Monoclonal

IgG2b

3H2

Mouse

Human, Rat

402

Murine

0.02 M PO4 buffer, 0.25M NaCI with 0.1% NaN3.

1.0 mg/ml

Store at 4 degree C.

ELISA (EIA), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blot (WB)

Biological Significance: Bone morphogenetic proteins (BMPs) are a group of growth factors also known as cytokines and as metabologens. Originally discovered by their ability to induce the formation of bone and cartilage, BMPs are now considered to constitute a group of pivotal morphogenetic signals, orchestrating tissue architecture throughout the body. BMP4 is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog.

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: BMP4 antibody was raised in mouse using recombinant mouse bone morphogenetic Protein 4 (BMP-4) as the immunogen.

Differentiation & Development

Mouse monoclonal BMP4 antibody

1311542

BAA06410.1

P12644

46,555 Da

Adipogenesis Pathway (198832); BMP Signaling Pathway (1084755); BMP Signaling Pathway (1108218); Basal Cell Carcinoma Pathway (83113); Basal Cell Carcinoma Pathway (525); Cardiac Progenitor Differentiation Pathway (712094); Elastic Fibre Formation Pathway (730310); Extracellular Matrix Organization Pathway (576262); Glypican 3 Network Pathway (138084); Heart Development Pathway (198802)

The protein encoded by this gene is a member of the bone morphogenetic protein family which is part of the transforming growth factor-beta superfamily. The superfamily includes large families of growth and differentiation factors. Bone morphogenetic proteins were originally identified by an ability of demineralized bone extract to induce endochondral osteogenesis in vivo in an extraskeletal site. This particular family member plays an important role in the onset of endochondral bone formation in humans, and a reduction in expression has been associated with a variety of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. Alternative splicing in the 5' untranslated region of this gene has been described and three variants are described, all encoding an identical protein. [provided by RefSeq, Jul 2008]

BMP4: Induces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction. Homodimer; disulfide-linked. Interacts with GREM2. Part of a complex consisting of TWSG1 and CHRD. Interacts with the serine proteases, HTRA1 and HTRA3; the interaction with either inhibits BMP4-mediated signaling. The HTRA protease activity is required for this inhibition. Interacts with SOSTDC1. Expressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines. Belongs to the TGF-beta family. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 14q22-q23. Cellular Component: extracellular space; proteinaceous extracellular matrix; extracellular region. Molecular Function: heparin binding; protein binding; growth factor activity; cytokine activity; transforming growth factor beta receptor binding; chemoattractant activity. Biological Process: negative regulation of MAP kinase activity; renal system process; extracellular matrix organization and biogenesis; macrophage differentiation; activation of MAPKK activity; positive regulation of apoptosis; positive regulation of transcription, DNA-dependent; negative regulation of chondrocyte differentiation; lymphoid progenitor cell differentiation; telencephalon regionalization; post-embryonic development; germ cell development; BMP signaling pathway; regulation of protein import into nucleus; positive regulation of endothelial cell differentiation; positive chemotaxis; erythrocyte differentiation; chondrocyte differentiation; mesonephros development; kidney development; endochondral ossification; regulation of odontogenesis of dentine-containing teeth; positive regulation of cardiac muscle fiber development; negative regulation of immature T cell proliferation in the thymus; specification of organ position; monocyte differentiation; neuron fate commitment; embryonic cranial skeleton morphogenesis; negative regulation of striated muscle development; branching morphogenesis of a tube; positive regulation of epidermal cell differentiation; negative regulation of mitosis; negative regulation of phosphorylation; positive regulation of endothelial cell proliferation; steroid hormone mediated signaling; positive regulation of transcription from RNA polymerase II promoter; hemopoietic progenitor cell differentiation; embryonic digit morphogenesis; negative regulation of transcription, DNA-dependent; alveolus development; positive regulation of epithelial cell proliferation; negative regulation of apoptosis; positive regulation of protein binding; positive regulation of smooth muscle cell proliferation; cloacal septation; positive regulation of collagen biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; embryonic hindlimb morphogenesis; negative regulation of cell cycle; odontogenesis; negative regulation of cell proliferation; smooth muscle development; inner ear receptor cell differentiation; ureteric bud development; intermediate mesodermal cell differentiation; regulation of smooth muscle cell differentiation; positive regulation of BMP signaling pathway; dorsoventral neural tube patterning; negative regulation of epithelial cell proliferation; smoothened signaling pathway; common-partner SMAD protein phosphorylation; negative regulation of T cell differentiation in the thymus; positive regulation of bone mineralization; positive regulation of ossification; odontogenesis of dentine-containing teeth; osteoblast differentiation; positive regulation of osteoblast differentiation; telencephalon development; blood vessel endothelial cell proliferation during sprouting angiogenesis; pituitary gland development; ureteric bud branching; neural tube closure; regulation of cell fate commitment; positive regulation of protein amino acid phosphorylation; positive regulation of neuron differentiation; negative regulation of myoblast differentiation; mesodermal cell fate determination; anterior/posterior axis specification. Disease: Orofacial Cleft 11; Microphthalmia, Syndromic 6

0.1 mg

605 USD