EPO antibody (HRP) | MyBioSource MBS530193 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

EPO antibody (HRP)

catalog :

MBS530193

quantity :

1 mg

price :

925 USD

clonality :

monoclonal

host :

mouse

conjugate :

HRP

clone name :

Epo1

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS530193

products type :

Antibody

products full name :

EPO antibody (HRP)

products short name :

EPO

products name syn :

Monoclonal EPO; Anti-EPO; EPO-a; Erythropoietin; Epoetin; EP; MGC138142; EPO-alpha; Erythropoietin-alpha

other names :

erythropoietin; Erythropoietin; erythropoietin; erythropoietin; INN: Epoetin

products gene name :

EPO

other gene names :

EPO; EPO; EP; MVCD2

uniprot entry name :

EPO_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

Epo1

host :

Mouse

reactivity :

Human

sequence length :

193

purity :

EPO antibody (HRP) was purified by chromatography on protein G Sepharose.

form :

Protein G purified and supplied in PBS, pH 7.4, with 0.02 % Thimerosal, 10mg/ml BSA and 50% glycerol.

concentration :

8.0mg/ml

storage stability :

Store at -20 degree C.

tested application :

ELISA (EIA), Western Blot (WB)

other info1 :

Biological Significance: Erythropoietin is a glycoprotein hormone that controls erythropoiesis, or red blood cell production. It is a cytokine for erythrocyte (red blood cell) precursors in the bone marrow. Erythropoietin is produced by the peritubular capillary endothelial cells in the kidney and liver, it is the hormone that regulates red blood cell production.

other info2 :

Biohazard Information: This product is sold as an antibody preparation for research use only. Standard Laboratory Practices should be followed when handling this material. This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling this product. Tag/Conjugate: HRP. Immunogen: EPO antibody (HRP) was raised in mouse using human EPO as the immunogen. Additional Remarks: Recommended pair for Sandwich ELISA: Epo2-Epo-1 (Capture-Conjugate)

products categories :

Hormones & Steroids; Conjugated Monoclonal Antibodies

products description :

Mouse monoclonal EPO antibody (HRP)

ncbi gi num :

312304

ncbi acc num :

CAA26095.1

uniprot acc num :

P01588

ncbi mol weight :

21,307 Da

ncbi pathways :

Cellular Response To Hypoxia Pathway (645259); Cellular Responses To Stress Pathway (645258); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); EPO Receptor Signaling Pathway (198882); EPO Signaling Pathway (138051); HIF-1 Signaling Pathway (695200); HIF-1-alpha Transcription Factor Network Pathway (138045); HIF-2-alpha Transcription Factor Network Pathway (137956); Hematopoietic Cell Lineage Pathway (83078)

ncbi summary :

This gene is a member of the EPO/TPO family and encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The protein is found in the plasma and regulates red cell production by promoting erythroid differentiation and initiating hemoglobin synthesis. This protein also has neuroprotective activity against a variety of potential brain injuries and antiapoptotic functions in several tissue types. [provided by RefSeq, Jul 2008]

uniprot summary :

EPO: Erythropoietin is the principal hormone involved in the regulation of erythrocyte differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Genetic variation in EPO is associated with susceptbility to microvascular complications of diabetes type 2 (MVCD2). These are pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis. Belongs to the EPO/TPO family. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 7q22. Cellular Component: extracellular space; cell surface; extracellular region. Molecular Function: protein binding; erythropoietin receptor binding; hormone activity; protein kinase activator activity. Biological Process: hemoglobin biosynthetic process; erythrocyte maturation; apoptosis; blood circulation; positive regulation of transcription, DNA-dependent; response to lipopolysaccharide; response to testosterone stimulus; signal transduction; response to salt stress; response to vitamin A; peptidyl-serine phosphorylation; response to hyperoxia; positive regulation of tyrosine phosphorylation of Stat5 protein; response to estrogen stimulus; positive regulation of protein kinase activity; positive regulation of cell proliferation; response to axon injury; positive regulation of Ras protein signal transduction; response to electrical stimulus; positive regulation of neuron differentiation; positive regulation of DNA replication; embryo implantation; aging. Disease: Microvascular Complications Of Diabetes, Susceptibility To, 2

size1 :

1 mg

price1 :

925 USD

more info or order :

MyBioSource product webpage