antibody

ApoA-I antibody

MBS530105

1 mg

430 USD

monoclonal

mouse

nonconjugated

M55311

human, cow

Antibody

ApoA-I antibody

ApoA-I

Monoclonal ApoA-I; Anti-ApoA-I; ApoA I; Apolipoprotein A-I; ApoA1; Apo AI

apolipoprotein A1, partial; Apolipoprotein A1; apolipoprotein A-I; apolipoprotein A-I; Apolipoprotein A1

ApoA-I

APOA1

Q9Y355_HUMAN

Monoclonal

IgG1

M55311

Mouse

Apo A-1: 100%. Apo A-II: 0%. Apo B: 0%

67

Human

> 90% pure. ApoA-I antibody was purified by Protein A chromatography.

Chromatographically purified IgG supplied in 15mM PO4, pH 7.4, with 0.1% NaN3.

5.1mg/ml

Store at 4 degree C for short term storage. Store at -20 degree C for long term storage. Avoid repeated freeze/thaw cycles.

User optimized

Biological Significance: 75% of Apo A in HDL is Apo AI. Levels of Apo AI are inversely related to the risk of coronary heart disease. Apo AI is also thought to activate LCAT (lecithin cholesterol acyl tranferase). In normal plasma, Apo AI levels range from 90-130 mg per 100 ml. Affinity Constant: ~8.0 x 10^9 Liters/Mole

Biohazard Information: This product contains sodium azide as preservative. Although the amount of sodium azide is very small appropriate care must be taken when handling. Immunogen: ApoA-I antibody was raised in mouse using human apolipoprotein A-1 (HDL) as the immunogen.

Cardiac Markers

Mouse monoclonal ApoA-I antibody

4960066

AAD34604.1

Q9Y355

ABC-family Proteins Mediated Transport Pathway (106573); ABCA Transporters In Lipid Homeostasis Pathway (477112); African Trypanosomiasis Pathway (194384); African Trypanosomiasis Pathway (194323); Amyloids Pathway (366238); Binding And Uptake Of Ligands By Scavenger Receptors Pathway (771599); Chylomicron-mediated Lipid Transport Pathway (106157); Disease Pathway (530764); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Fat Digestion And Absorption Pathway (194385)

This gene encodes apolipoprotein A-I, which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. This gene is closely linked with two other apolipoprotein genes on chromosome 11. Defects in this gene are associated with HDL deficiencies, including Tangier disease, and with systemic non-neuropathic amyloidosis. [provided by RefSeq, Jul 2008]

APOA1: Participates in the reverse transport of cholesterol from tissues to the liver for excretion by promoting cholesterol efflux from tissues and by acting as a cofactor for the lecithin cholesterol acyltransferase (LCAT). As part of the SPAP complex, activates spermatozoa motility. Interacts with APOA1BP and CLU. Component of a sperm activating protein complex (SPAP), consisting of APOA1, an immunoglobulin heavy chain, an immunoglobulin light chain and albumin. Interacts with NDRG1. Major protein of plasma HDL, also found in chylomicrons. Synthesized in the liver and small intestine. The oxidized form at Met-110 and Met-136 is increased in individuals with increased risk for coronary artery disease, such as in carrier of the eNOSa/b genotype and exposure to cigarette smoking. It is also present in increased levels in aortic lesions relative to native ApoA-I and increased levels are seen with increasing severity of disease. Belongs to the apolipoprotein A1/A4/E family. Protein type: Vesicle; Lipid-binding; Cell development/differentiation; Secreted; Motility/polarity/chemotaxis; Secreted, signal peptide; Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 11q23-q24. Cellular Component: extracellular space; chylomicron; cell surface; endoplasmic reticulum lumen; endocytic vesicle; early endosome; extracellular region; plasma membrane; cytoplasmic vesicle; nucleus; cytosol; vesicle. Molecular Function: identical protein binding; protein binding; enzyme binding; phospholipid transporter activity; lipase inhibitor activity; chemorepellent activity; cholesterol transporter activity; beta-amyloid binding; cholesterol binding; phospholipid binding; phosphatidylcholine binding; high-density lipoprotein binding; apolipoprotein A-I receptor binding; apolipoprotein receptor binding. Biological Process: phototransduction, visible light; negative chemotaxis; negative regulation of lipase activity; axon regeneration in the peripheral nervous system; negative regulation of interleukin-1 beta secretion; sequestering of lipid; regulation of cholesterol absorption; transforming growth factor beta receptor signaling pathway; positive regulation of stress fiber formation; response to drug; platelet activation; cholesterol metabolic process; organ regeneration; regulation of Cdc42 protein signal transduction; adrenal gland development; positive regulation of hydrolase activity; positive regulation of Rho protein signal transduction; lipoprotein metabolic process; positive regulation of transferase activity; vitamin transport; cholesterol biosynthetic process; negative regulation of cytokine secretion during immune response; cholesterol homeostasis; lipoprotein biosynthetic process; response to estrogen stimulus; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; positive regulation of lipoprotein lipase activity; blood vessel endothelial cell migration; cellular lipid metabolic process; platelet degranulation; phospholipid efflux; retinoid metabolic process; transmembrane transport; response to nutrient; phospholipid homeostasis; integrin-mediated signaling pathway; positive regulation of fatty acid biosynthetic process; receptor-mediated endocytosis; regulation of protein amino acid phosphorylation; cholesterol transport; protein stabilization; negative regulation of heterotypic cell-cell adhesion; protein amino acid oxidation; neurite regeneration; cholesterol efflux; glucocorticoid metabolic process; G-protein coupled receptor protein signaling pathway; reverse cholesterol transport; negative regulation of inflammatory response; endothelial cell proliferation; blood coagulation. Disease: Hypoalphalipoproteinemia, Primary; Amyloidosis, Familial Visceral

1 mg

430 USD