antibody

Anti-Mouse CD86, Purified (Clone RMMP-2) (rat IgG2a)

MBS520473

0.2 mg

385 USD

monoclonal

rat

nonconjugated

RMMP-2

human, mouse

Antibody

Anti-Mouse CD86, Purified (Clone RMMP-2) (rat IgG2a)

CD86

CD86, Purified (Clone RMMP-2) (rat IgG2a); Purified Anti-Mouse CD86 (B7-2) Monoclonal Antibody

CD86; T-lymphocyte activation antigen CD86; T-lymphocyte activation antigen CD86; BU63; FUN-1; CTLA-4 counter-receptor B7.2; B-lymphocyte activation antigen B7-2; CD86 antigen (CD28 antigen ligand 2, B7-2 antigen); CD86 molecule; Activation B7-2 antigen; B70; BU63; CTLA-4 counter-receptor B7.2; FUN-1

CD86

CD86; CD86; B70; B7-2; B7.2; LAB72; CD28LG2; CD28LG2

CD86_HUMAN

Monoclonal

Rat IgG2a

RMMP-2

Rat

Mouse

323

CD86 (B7-2, B70) (Mouse CD86 (B7-2))

Purified (Purified Ig buffered in PBS, 0.1% NaN3 and EIA grade BSA to bring total protein concentration to 4-5 mg/ml.)

Antibody Concentration: 0.2 mg/ml

Store at 4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles. If the reagent is being diluted, it is recommended that only the quantity to be used within one week be diluted. Check label for expiry date.

Immunohistochemistry (IHC)

Presentation: 200 ug purified Ig buffered in PBS and 0.1% NaN3

anti-mouse B7-2 monoclonal antibody reacts with a co-stimulatory molecule expressed on antigen-presenting cells, dendritic cells and activated B cells within 24 hours of stimulation by LPS, anti-CD40, anti-surface Ig, or specific antigen. B7-2, a ligand of CD28 and CTLA-4, is one of the accessory molecules that plays an important role in T cell-B cell co-stimulatory interactions. This antibody is suitable for use in flow cytometry.

49456643

CAG46642.1

P42081

37,682 Da

Adaptive Immune System Pathway 366160!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!CD28 Co-stimulation Pathway 119553!!CD28 Dependent PI3K/Akt Signaling Pathway 119554!!CD28 Dependent Vav1 Pathway 119555!!CTLA4 Inhibitory Signaling Pathway 119556!!Cell Adhesion Molecules (CAMs) Pathway 83069

This gene encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.[provided by RefSeq, May 2011]

Function: Receptor involved in the costimulatory signal essential for T-lymphocyte proliferation and interleukin-2 production, by binding CD28 or CTLA-4. May play a critical role in the early events of T-cell activation and costimulation of naive T-cells, such as deciding between immunity and anergy that is made by T-cells within 24 hours after activation. Isoform 2 interferes with the formation of CD86 clusters, and thus acts as a negative regulator of T-cell activation. Subunit structure: Homodimer. Interacts with MARCH8. Interacts with human herpesvirus 8 MIR2 protein . Probable. Interacts with adenovirus subgroup B fiber proteins and acts as a receptor for these viruses. Ref.12 Ref.13 Ref.15. Subcellular location: Cell membrane; Single-pass type I membrane protein. Tissue specificity: Expressed by activated B-lymphocytes and monocytes. Post-translational modification: Polyubiquitinated; which is promoted by MARCH8 and results in endocytosis and lysosomal degradation. Sequence similarities: Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 Ig-like V-type (immunoglobulin-like) domain.

0.2 mg

385 USD