product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-Human Platelet Factor 4, Biotin (Clone: RTO) (Mouse IgG2b)
catalog :
MBS520471
quantity :
0.1 mg
price :
315 USD
clonality :
monoclonal
host :
mouse
conjugate :
biotin
clone name :
RTO
reactivity :
human
application :
western blot, ELISA, enzyme immunoassay
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS520471
products type :
Antibody
products full name :
Anti-Human Platelet Factor 4, Biotin (Clone: RTO) (Mouse IgG2b)
products short name :
Platelet Factor 4
products name syn :
Platelet Factor 4, Biotin (Clone: RTO) (Mouse IgG2b); Anti-Human Platelet Factor IV
other names :
platelet factor 4; Platelet factor 4 variant; platelet factor 4 variant; PF4alt; PF4var1; C-X-C motif chemokine 4; platelet factor 4, variant 1 (PF4-like); platelet factor 4 variant 1; C-X-C motif chemokine 4 variant; CXCL4L1; PF4alt; PF4var1
other gene names :
PF4V1; PF4V1; PF4A; CXCL4L1; CXCL4V1; PF4-ALT; SCYB4V1; CXCL4V1; SCYB4V1
uniprot entry name :
PF4V_HUMAN
clonality :
Monoclonal
isotype :
Mouse IgG2bkappa
clone :
RTO
host :
Mouse
reactivity :
Human
sequence length :
104
specificity :
Platelet Factor 4 (This antibody is specific for Human Platelet Factor IV.)
form :
Biotin
concentration :
0.1 mg/ml
storage stability :
Store at +4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single use. Avoid freeze thaw cycles
tested application :
ELISA (EIA), Western Blot (WB)
app notes :
This antibody is suitable for use in ELISA and Western Blot.
other info1 :
Immunogen: Human Factor IV purified from the supernatant of thrombin activated platelets.
other info2 :
Presentation: Biotin conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
products description :
Platelet factor IV is a 70 aa protein released from the alpha granules of activated platelets. PF4 is synthesized by bone marrow megakaryocytes and stored in alpha granules as a non-covalent bound tetramer. Platelet factor IV binds with high affinity to heparin and plays a role in inflammation and wound repair. PF4 is a chemoattractant for neutrophils, monocytes and fibroblasts and has been reported to be an immunologic regulator that inhibits suppressor T-cell activity. (clone RTO) is seen to bind free PF4 in the absence of any bound heparin. This is unlike (clone KKO), which binds PF4/heparin complexes to a similar degree as auto-antibodies found in individuals with Heparin-Induced Thrombocytopenia/Thrombosis (HIT/HITT).
ncbi gi num :
292390
ncbi acc num :
AAA60067.1
uniprot acc num :
P10720
ncbi mol weight :
11,553 Da
ncbi pathways :
Cell Surface Interactions At The Vascular Wall Pathway 106062!!Chemokine Signaling Pathway 99051!!Chemokine Signaling Pathway 96864!!Common Pathway 106060!!Cytokine-cytokine Receptor Interaction Pathway 83051!!Cytokine-cytokine Receptor Interaction Pathway 460!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057!!Hemostasis Pathway 106028
uniprot summary :
Function: Inhibitor of angiogenesis. Inhibitor of endothelial cell chemotaxis (in vitro). Ref.5. Subunit structure: Homotetramer. Ref.6. Subcellular location: Secreted. Post-translational modification: The N-terminal processed forms of platelet factor 4 variant seems to be produced by proteolytic cleavage. The most abundant form is Platelet factor 4 variant(5-74). Miscellaneous: Binding to heparin is much weaker than in the close homolog PF4/CXCL4. Sequence similarities: Belongs to the intercrine alpha (chemokine CxC) family. Mass spectrometry: Molecular mass is 8250.9 Da from positions 31 - 104. Determined by ESI. Platelet factor 4 variant. Ref.5Molecular mass is 7877.7 Da from positions 34 - 104. Determined by ESI. Platelet factor 4 variant(4-74). Ref.5Molecular mass is 7805.8 Da from positions 35 - 104. Determined by ESI. Platelet factor 4 variant(5-74). Ref.5Molecular mass is 7678.6 Da from positions 36 - 104. Determined by ESI. Platelet factor 4 variant(6-74). Ref.5
size :
0.1 mg
price :
315 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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