product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-Mouse TIM3, FITC, (clone: 25F.1D6), (rat IgG2ak)
catalog :
MBS520440
quantity :
0.1 mg
price :
255 USD
clonality :
monoclonal
host :
rat
conjugate :
FITC
clone name :
25F.1D6
reactivity :
human
application :
immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS520440
products type :
Antibody
products full name :
Anti-Mouse TIM3, FITC, (clone: 25F.1D6), (rat IgG2ak)
products short name :
TIM3
products name syn :
TIM3, FITC, (clone: 25F.1D6), (rat IgG2ak); Anti-Mouse Tim-3 Receptor Monoclonal Antibody
other names :
T cell immunoglobulin mucin-3
products gene name :
TIM3
clonality :
Monoclonal
isotype :
Rat IgG2akappa
clone :
25F.1D6
host :
Rat
reactivity :
Mouse
sequence length :
301
specificity :
TIM3 (Mouse Tim-3 type 1 transmembrane protein)
form :
FITC
concentration :
0.1mg/ml
storage stability :
For all formats, store at 4 degree C. DO NOT FREEZE PE conjugates. For long term storage (Purified, Biotin, FITC, No Azide), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
tested application :
Immunohistochemistry (IHC)
other info2 :
Presentation: Biotin/FITC/PE conjugated IgG buffered in PBS, 0.02% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
products description :
anti-mouse Tim-3 (T cell immunoglobulin domain, mucin domain 3) monoclonal antibody reacts with mouse Tim-3. This 281 amino acid type 1 transmembrane protein contains an immunoglobulin and mucin-like domain in its extra-cellular portion and a tyrosine phosphorylation motif in its cytoplasmic portion. Tim-3 is a member of the immunoglobulin super-family and is expressed on Th1 lymphocytes and CD11b+ macrophages. Tim-3 is a T helper type 1 (TH1)-specific molecule that regulates TH1 mediated auto and alloimmune responses and the induction of peripheral immunological tolerance. This antibody has been reported to work in Flow Cytometry and Immunohistochemistry. This FITC conjugated format is especially useful for direct flow cytometry.
ncbi gi num :
18182535
ncbi acc num :
AAL65158.1
ncbi summary :
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011]
uniprot summary :
TIM-3: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9. Belongs to the immunoglobulin superfamily. TIM family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 5q33.3. Cellular Component: integral to membrane. Disease: Rheumatoid Arthritis
size1 :
0.1 mg
price1 :
255 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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