Anti-Mouse CD40, Biotin (Clone 3/23) (rat IgG2a) | MyBioSource MBS520120 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Mouse CD40, Biotin (Clone 3/23) (rat IgG2a)

catalog :

MBS520120

quantity :

0.1 mg

price :

200 USD

clonality :

monoclonal

host :

rat

conjugate :

biotin

clone name :

23-Feb

reactivity :

human, mouse

application :

immunohistochemistry, flow cytometry, FACS

product information

catalog number :

MBS520120

products type :

Antibody

products full name :

Anti-Mouse CD40, Biotin (Clone 3/23) (rat IgG2a)

products short name :

CD40

products name syn :

CD40, Biotin (Clone 3/23) (rat IgG2a); Biotin Anti-Mouse CD40 Monoclonal Antibody

other names :

tumor necrosis factor receptor superfamily member 5 isoform 2; Tumor necrosis factor receptor superfamily member 5; tumor necrosis factor receptor superfamily member 5; CD40L receptor; CD40 type II isoform; B cell-associated molecule; B cell surface antigen CD40; B-cell surface antigen CD40; CD40 antigen (TNF receptor superfamily member 5); tumor necrosis factor receptor superfamily, member 5; nerve growth factor receptor-related B-lymphocyte activation molecule; CD40 molecule, TNF receptor superfamily member 5; B-cell surface antigen CD40; Bp50; CD40L receptor; CDw40

products gene name :

CD40

other gene names :

CD40; CD40; p50; Bp50; CDW40; TNFRSF5; TNFRSF5

uniprot entry name :

TNR5_HUMAN

clonality :

Monoclonal

isotype :

Rat IgG2a

clone :

23-Feb

host :

Rat

reactivity :

Mouse

sequence length :

203

specificity :

CD40 (gp39 receptor) (Mouse CD40)

form :

Biotin

concentration :

Antibody Concentration: 0.1 mg/ml

storage stability :

Store at 4 degree C. For long term storage, aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles. Check label for expiry date.

tested application :

Immunohistochemistry (IHC), Flow Cytometry (FC/FACS)

other info2 :

Presentation: 100 ug or 300 ug Biotin conjugated Ig buffered in PBS, 0.1% NaN3 and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.

products description :

anti-mouse monoclonal antibody reacts with CD40 which is expressed on B-lymphocytes and on a subset of both CD4+ and CD8+ T cells in the adult (but not neonatal) spleen1. The level of CD40 on B cells is enhanced following activation buy LPS1. The interactions of CD40 with its ligand CD40L are responsible for generating humoral responses, germinal center formation, and generating B cell memory2. Stimulating cells with immobilized 3/23 mAb increases expression of CD86 (B7.2) on B cells1,3. Though the 3/23 mAb itself is a weak mitogen, it produces a synergistic proliferative B cell response with IL-4 or with mitogenic antibodies against surface Ig 1,3. Costimulation with 3/23 mAb and IL-4 rescues B cells from apoptosis induced by hypercross-linking of sIgM or sIgD3. This antibody is suitable for use in flow cytometry. Other applications of this antibody include IHC of acetonefixed frozen sections2.

ncbi gi num :

23312371

ncbi acc num :

NP_690593.1

ncbi gb acc num :

NM_152854.2

uniprot acc num :

P25942

ncbi mol weight :

30,619 Da

ncbi pathways :

Adaptive Immune System Pathway 366160!!Allograft Rejection Pathway 83123!!Allograft Rejection Pathway 535!!Asthma Pathway 83120!!Asthma Pathway 532!!Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!CD40/CD40L Signaling Pathway 138061!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480

ncbi summary :

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been found to be essential in mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

Function: Receptor for TNFSF5/CD40LG. Subunit structure: Monomer and homodimer. The variant form found in the bladder carcinoma cell line Hu549 does not form homodimers. Interacts with TRAF1, TRAF2, TRAF3, TRAF5 and TRAF6. Ref.11 Ref.14 Ref.15 Ref.16 Ref.17 Ref.18. Subcellular location: Isoform I: Cell membrane; Single-pass type I membrane protein. Isoform II: Secreted. Tissue specificity: B-cells and in primary carcinomas. Involvement in disease: Immunodeficiency with hyper-IgM 3 (HIGM3) [MIM:606843]: A rare immunodeficiency syndrome characterized by normal or elevated serum IgM levels with absence of IgG, IgA, and IgE. It results in a profound susceptibility to bacterial infections.Note: The disease is caused by mutations affecting the gene represented in this entry. Ref.23. Sequence similarities: Contains 4 TNFR-Cys repeats.

size :

0.1 mg

price :

200 USD