catalog number :
MBS520104
products full name :
Anti-Mouse CD4 APC (Clone CT-CD4) (rat IgG2a)
products short name :
CD4
products name syn :
CD4 APC (Clone CT-CD4) (rat IgG2a); APC Anti-Mouse CD4 (L3/T4) Monoclonal Antibody
other names :
CD4; CD4 protein; T-cell surface glycoprotein CD4; CD4 receptor; CD4 antigen (p55); T-cell surface antigen T4/Leu-3; CD4 molecule
other gene names :
CD4; CD4; CD4mut; CD4 receptor
uniprot entry name :
Q13969_HUMAN
specificity :
CD4 (L3/T4; Ly4) (Mouse CD4)
storage stability :
Store at 4 degree C. DO NOT FREEZE. Avoid prolonged exposure to light. If the reagent is being diluted, it is recommended that only the quantity to be used within one week be diluted. Check label for expiry date.
tested application :
Immunohistochemistry (IHC)
other info2 :
Presentation: 100 ug APC conjugated Ig buffered in 0.5ml PBS containing 0.1% sodium azide and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/ml.
products description :
This monoclonal antibody (mAb) recognizes mouse CD4 (L3T4) which is expressed on the majority of thymocytes and on the MHC class II restricted subset of mature T cells including Th cells1,2. Mouse CD4 has also been reported to be present on multipotential hematopoietic stem cells, bone marrow myeloid precursors, and intrathymic precursors2,3. As a coreceptor in the TCR complex, CD4 is involved in T cell activation through interaction with MHC class II on APC's and in signal transduction via protein tyrosine kinase lck1. This antibody is suitable for use in flow cytometry and is reported to work in immunohistochemistry on acetone fixed frozen sections.
ncbi acc num :
CAA60883.1
ncbi mol weight :
7,844 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Alpha-defensins Pathway 530758!!Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!Arf1 Pathway 137927!!Binding And Entry Of HIV Virion Pathway 105986!!C-MYB Transcription Factor Network Pathway 138073!!CXCR4-mediated Signaling Events Pathway 137910!!Cell Adhesion Molecules (CAMs) Pathway 83069!!Cell Adhesion Molecules (CAMs) Pathway 480
ncbi summary :
This gene encodes a membrane glycoprotein of T lymphocytes that interacts with major histocompatibility complex class II antigenes and is also a receptor for the human immunodeficiency virus. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, and granulocytes. It is also expressed in specific regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, Aug 2010]