product summary
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company name :
MyBioSource
product type :
antibody
product name :
Anti-Human CD180 (TLR4/RP105), Purified (Clone: G28.8) (mouse IgG1)
catalog :
MBS520063
quantity :
0.2 mg
price :
315 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G28.8
reactivity :
human
application :
immunohistochemistry
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS520063
products type :
Antibody
products full name :
Anti-Human CD180 (TLR4/RP105), Purified (Clone: G28.8) (mouse IgG1)
products short name :
CD180 (TLR4/RP105)
products name syn :
CD180 (TLR4/RP105), Purified (Clone: G28.8) (mouse IgG1); Anti-Human RP105 (CD180) Monoclonal Antibody
other names :
RP105; CD180 antigen; CD180 antigen; lymphocyte antigen 64; radioprotective 105 kDa protein; lymphocyte antigen-64, radioprotective, 105kDa; CD180 molecule; Lymphocyte antigen 64; Radioprotective 105 kDa protein
products gene name :
CD180 (TLR4/RP105)
other gene names :
CD180; CD180; LY64; Ly78; RP105; LY64; RP105
uniprot entry name :
CD180_HUMAN
clonality :
Monoclonal
isotype :
Mouse IgG1kappa
clone :
G28.8
host :
Mouse
reactivity :
Human
sequence length :
661
specificity :
RP105 (CD180) (Human RP105 (CD180))
form :
Purified
concentration :
1.0 mg/ml
storage stability :
For all formats, store at 4 degree C. DO NOT FREEZE PE conjugates. For long term storage (Purified, Biotin, FITC, No Azide), aliquot and freeze unused portion at -20 degree C in volumes appropriate for single usage. Avoid freeze/thaw cycles.
tested application :
Immunohistochemistry (IHC)
other info1 :
Immunogen: Human RP105. Donor: mouse ascites fluid
other info2 :
Presentation: Purified IgG buffered in PBS and 0.02% NaN3. (Purified from ascitic fluid via Protein G Chromatography).
products description :
anti-human RP105 (CD180, Bgp95), is a 95-105 kDa type 1 membrane protein that forms a cell surface receptor complex with a molecule called MD1 and is a member of the toll like receptor (TLR) family. The RP105/MD1 complex is a component of the innate immune system and in combination with TLR4 controls B cell recognition and signaling of LPS on gram negative bacteria. RP105 is expressed mainly on mature peripheral B cells. This anti-body has been reported to work in Flow Cytometry.
ncbi gi num :
1843411
ncbi acc num :
BAA12019.1
uniprot acc num :
Q99467
ncbi mol weight :
74,179 Da
ncbi pathways :
Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Toll Like Receptor 4 (TLR4) Cascade Pathway 106398!!Toll-Like Receptors Cascades Pathway 106388
ncbi summary :
CD180 is a cell surface molecule consisting of extracellular leucine-rich repeats (LRR) and a short cytoplasmic tail. The extracellular LRR is associated with a molecule called MD-1 and form the cell surface receptor complex, RP105/MD-1. It belongs to the family of pathogen receptors, Toll-like receptors (TLR). RP105/MD1, by working in concert with TLR4, controls B cell recognition and signaling of lipopolysaccharide (LPS), a membrane constituent of Gram-negative bacteria. [provided by RefSeq, Jul 2008]
uniprot summary :
Function: May cooperate with MD-1 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) in B-cells. Leads to NF-kappa-B activation. Also involved in the life/death decision of B-cells . By similarity. Subunit structure: M-shaped tetramer of two CD180-LY86 heterodimers. Ref.9. Subcellular location: Cell membrane; Single-pass type I membrane protein. Tissue specificity: Expressed mainly on mature peripherical B cells. Detected in spleen, lymph node and appendix. Not detected in pre-B and -T cells. Sequence similarities: Belongs to the Toll-like receptor family.Contains 19 LRR (leucine-rich) repeats.Contains 1 LRRCT domain.Contains 1 LRRNT domain.
size :
0.2 mg
price :
315 USD
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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