protein

WWP2, Active Full-length human recombinant protein expressed in Sf9 cells

MBS515710

0.25 mg

3200 USD

Recombinant Protein

WWP2, Active Full-length human recombinant protein expressed in Sf9 cells

[WWP2]

[WWP2]

[AIP2; WWp2-like]

>90%

Recombinant proteins stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

0.2 ug/ul

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Shipping: Ships with Dry Ice. Stability: 1yr at -70°C from date of shipment

Specific Activity

Purity Data

Specific Activity: 53 nmol/min/mg

Recombinant full-length human WWP2 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The WWP2 gene accession number is NM_007014. WWP2 or WW domain containing E3 ubiquitin protein ligase 2 is a member of the Nedd4 family of E3 ligases, which play an important role in protein ubiquitination. WWP2 contains four WW domains and may play a role in multiple processes including chondrogenesis and the regulation of oncogenic signaling pathways via interactions with Smad proteins and the tumor suppressor PTEN. WWP2 is an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. WWP2 which is also called AIP2 can bind to atrophin-1.

1. Xu, H.M. et al: Wwp2, an E3 ubiquitin ligase that targets transcription factor Oct-4 for ubiquitination. J. Biol. Chem. 279: 23495-23503, 2004. 2. Wood, J.D. et al: Atrophin-1, the DRPLA gene product, interacts with two families of WW domain-containing proteins. Mol. Cell. Neurosci. 11: 149-160, 1998

NM_007014

0.25 mg

3200 USD

0.5 mg

4055

1 mg

5520