protein

RIPK1, Active

MBS515438

0.005 mg

415 USD

Recombinant Protein

RIPK1, Active

RIPK1

RIPK1

>70%

Recombinant protein stored in 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

0.1ug/ul

Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. 1 year at -70 degree C from date of shipment. Shipping: Ships with Dry Ice.

Gene Aliases: RCK; MAP3K19. Specific Activity: 3.6 nmol/min/mg

Full-length recombinant human RIPK1 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The RIPK1 gene accession number is NM_003804. RIPK1 or Receptor Interacting Protein Kinase 1 is a serine/threonine kinase that was originally identified as interacting with the cytoplasmic domain of FAS. RIPK1 has been deemed as an important element in the signal transduction machinery that mediates programmed cell death. RIPK1 has been shown to interact with TRADD, TRAF1 TRAF2 and TRAF3 and TRADD can act as an adaptor protein to recruit RIPK1 to the TNFR1 complex in a TNF-dependent process (1). TNF? is capable of activating the noncanonical NF- k B pathway, but this activation of this pathway is negatively regulated by RIPK1 (2).

0.005 mg

415 USD

0.01 mg

580