protein

PAD6 recombinant protein

MBS515212

0.02 mg

270 USD

Recombinant Protein

PAD6 recombinant protein

[PAD6]

[PADI6]

[Homo sapiens peptidyl arginine deiminase, type VI (PADI6), mRNA; Protein-arginine deiminase type-6; protein-arginine deiminase type-6; peptidylarginine deiminase type 6; peptidyl arginine deiminase-like protein; peptidyl arginine deiminase, type VI; Peptidyl arginine deiminase-like protein; Peptidylarginine deiminase VI; hPADVI; Protein-arginine deiminase type VI]

[PAD6]

[PADI6; PADI6; hPADVI; hPADVI]

PADI6_HUMAN

Sf9 insect cells

2346

Recombinant protein stored in 50mM Tris-HCI, pH 7.5, 50mM NaCI, 10 mM glutathione,0.1 mM EDTA, 0.25mM DTT, 0.01 PMSF, 25% glycerol.

0.1ug/ul

Store product at -70°C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Stability: 1 year at -70°C from date of shipment.

Western Blot (WB)

Test Data

Type: Recombinant Fusion Protein. Species: Human. Tag Information: N-terminal GST. Source Note: Recombinant full-length human PAD6 was expressed by baculovirus in Sf9 insect cells

Arginine Deiminases Proteins

Recombinant full-length human PAD6 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_207421. Scientific Background PAD6 or PADI6 is a member of the peptidylarginine deiminases which convert arginine residues to citru lline residues in the presence of calcium ions. The PAD family members are thought to be involved in multiple sclerosis and rheumatoid arthritis pathophysiology, and they play a role in epidermis homeostasis 1). PAD6 is essent ial for formation of a novel oocyte-restricted fibrous structure, the cytoplasmic lattices CPLs). PAD6/CPL superstru cture plays a key role in regulating microtubule-mediated organelle positioning and movement (2).

117414157

NP_997304.3

NM_207421

Q6TGC4

100 kDa

Protein Citrullination Pathway (142167); Protein Citrullination Pathway (138213)

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. This protein may play a role in cytoskeletal reorganization in the egg and in early embryo development. [provided by RefSeq, Sep 2012]

Function: Catalyzes the deimination of arginine residues of proteins. May be involved in cytoskeletal reorganization in the egg and early embryo . By similarity. Catalytic activity: Protein L-arginine + H2O = protein L-citrulline + NH3. Cofactor: Calcium . By similarity. Subcellular location: Cytoplasm . By similarity. Nucleus . By similarity. Tissue specificity: Ovary, testis and peripheral blood leukocytes. Ref.1. Sequence similarities: Belongs to the protein arginine deiminase family.

0.02 mg

270 USD

0.05 mg

450