protein

PAD3 protein. Full length recombinant human protein expressed in Sf9 cells.

MBS515150

0.02 mg

260 USD

Recombinant Protein

PAD3 protein. Full length recombinant human protein expressed in Sf9 cells.

PAD3

MGC126307; MGC126308; PADI3; PDI3

Homo sapiens peptidyl arginine deiminase, type III (PADI3), mRNA; Protein-arginine deiminase type-3; protein-arginine deiminase type-3; peptidylarginine deiminase III; protein-arginine deiminase type III; peptidyl arginine deiminase, type III; Peptidylarginine deiminase III; Protein-arginine deiminase type III

PAD3

PADI3; PADI3; PAD3; PDI3; PDI3

PADI3_HUMAN

Sf9 insect cells

3189

>95%

50mM Tris-HCl, pH 7.5, 50mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol.

0.1ug/ul

Store product at -70 degree C. For optimal storage, aliquot target into smaller quantities after centrifugation and store at recommended temperature. For most favorable performance, avoid repeated handling and multiple freeze/thaw cycles. Stability: 1 yr at -70 degree C from date of shipment. Shipping: Ships with Dry Ice.

Western Blot (WB)

Type: Recombinant Fusion Protein. Species: Human. Tag Information: N-terminal GST. Source Note: Recombinant full-length human PAD3 was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. The gene accession number is NM_016233.

Arginine Deiminases Proteins

Background: PAD3 is a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. PAD3 modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. It converts arginine to citrulline in filaggrin at a faster rate than it does in trichohyalin (1). Together with the type I enzyme (PAD1), PAD3 play a role in terminal differentiation of the epidermis.

122939160

NP_057317.2

NM_016233

Q9ULW8

97 kDa

Protein Citrullination Pathway (142167); Protein Citrullination Pathway (138213)

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes. [provided by RefSeq, Jul 2008]

Function: Catalyzes the deimination of arginine residues of proteins. Catalytic activity: Protein L-arginine + H2O = protein L-citrulline + NH3. Cofactor: Calcium . By similarity. Subcellular location: Cytoplasm. Tissue specificity: Hair follicles, and epidermis at very low levels. Sequence similarities: Belongs to the protein arginine deiminase family.

0.02 mg

260 USD

0.05 mg

415