Sheep anti-human Neutrophil Elastase, Purified IgG | MyBioSource MBS512102 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Sheep anti-human Neutrophil Elastase, Purified IgG

catalog :

MBS512102

quantity :

10 mg

price :

260 USD

clonality :

polyclonal

host :

sheep

conjugate :

nonconjugated

reactivity :

human

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS512102

products type :

Antibody

products full name :

Sheep anti-human Neutrophil Elastase, Purified IgG

products short name :

Neutrophil Elastase

products name syn :

Neutrophil Elastase, human

other names :

neutrophil elastase preproprotein; Neutrophil elastase; neutrophil elastase; elastase-2; medullasin; PMN elastase; leukocyte elastase; elastase 2, neutrophil; human leukocyte elastase; polymorphonuclear elastase; bone marrow serine protease; granulocyte-derived elastase; elastase, neutrophil expressed; Bone marrow serine protease; Elastase-2; Human leukocyte elastase; HLE; Medullasin; PMN elastase

other gene names :

ELANE; ELANE; GE; NE; HLE; HNE; ELA2; SCN1; PMN-E; ELA2

uniprot entry name :

ELNE_HUMAN

clonality :

Polyclonal

host :

Sheep

specificity :

This antibody is specific for neutrophil elastase as demonstrated by immunoelectrophoresis and ELISA.

purity :

Purified IgG

storage stability :

Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use.

app notes :

This product is suitable as a source of antibodies to neutrophil elastase.

other info1 :

Immunogen: Neutrophil elastase (active-site blocked) prepared from human sputum. Presentation: XXXX ml of immunoglobulin purified from sheep antiserum. The IgG concentration is XXXX mg/ml in 10 mM HEPES, pH 7.4, containing 0.15 M NaCl and 50% glycerol (v/v). Total protein is 10 mg.

ncbi gi num :

4503549

ncbi acc num :

NP_001963.1

ncbi gb acc num :

NM_001972.2

uniprot acc num :

P08246

ncbi mol weight :

28,518 Da

ncbi pathways :

C-MYB Transcription Factor Network Pathway 138073!!Systemic Lupus Erythematosus Pathway 83122!!Systemic Lupus Erythematosus Pathway 534!!Amb2 Integrin Signaling Pathway 137945

ncbi summary :

Elastases form a subfamily of serine proteases that hydrolyze many proteins in addition to elastin. Humans have six elastase genes which encode the structurally similar proteins. The product of this gene hydrolyzes proteins within specialized neutrophil lysosomes, called azurophil granules, as well as proteins of the extracellular matrix following the protein's release from activated neutrophils. The enzyme may play a role in degenerative and inflammatory diseases by its proteolysis of collagen-IV and elastin of the extracellular matrix. This protein degrades the outer membrane protein A (OmpA) of E. coli as well as the virulence factors of such bacteria as Shigella, Salmonella and Yersinia. Mutations in this gene are associated with cyclic neutropenia and severe congenital neutropenia (SCN). This gene is clustered with other serine protease gene family members, azurocidin 1 and proteinase 3 genes, at chromosome 19pter. All 3 genes are expressed coordinately and their protein products are packaged together into azurophil granules during neutrophil differentiation. [provided by RefSeq]

uniprot summary :

Function: Modifies the functions of natural killer cells, monocytes and granulocytes. Inhibits C5a-dependent neutrophil enzyme release and chemotaxis. Ref.15. Catalytic activity: Hydrolysis of proteins, including elastin. Preferential cleavage: Val- -Xaa > Ala- -Xaa. Subunit structure: Interacts with NOTCH2NL. Ref.16. Tissue specificity: Bone marrow cells. Involvement in disease: Defects in ELANE are a cause of cyclic haematopoiesis (CH) [. MIM:162800]; also known as cyclic neutropenia. CH is an autosomal dominant disease in which blood-cell production from the bone marrow oscillates with 21-day periodicity. Circulating neutrophils vary between almost normal numbers and zero. During intervals of neutropenia, affected individuals are at risk for opportunistic infection. Monocytes, platelets, lymphocytes and reticulocytes also cycle with the same frequency. Ref.16 Ref.21Defects in ELANE are the cause of neutropenia severe congenital autosomal dominant type 1 (SCN1) [. MIM:202700]. SCN1 is a disorder of hematopoiesis characterized by a maturation arrest of granulopoiesis at the level of promyelocytes with peripheral blood absolute neutrophil counts below 0.5 x 109/l and early onset of severe bacterial infections. Ref.26. Sequence similarities: Belongs to the peptidase S1 family. Elastase subfamily.Contains 1 peptidase S1 domain. Sequence caution: The sequence CAA29300.1 differs from that shown. Reason: Erroneous initiation.

size :

10 mg

price :

260 USD

more info or order :

MyBioSource product webpage