Goat anti-human alpha2Antiplasmin (alpha2AP), Whole IgG from antiserum | MyBioSource MBS512006 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Goat anti-human alpha2Antiplasmin (alpha2AP), Whole IgG from antiserum

catalog :

MBS512006

quantity :

5 mg

price :

280 USD

clonality :

polyclonal

host :

goat

conjugate :

nonconjugated

reactivity :

mouse

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS512006

products type :

Antibody

products full name :

Goat anti-human alpha2Antiplasmin (alpha2AP), Whole IgG from antiserum

products short name :

alpha2-Antiplasmin

products name syn :

alpha2-Antiplasmin, human

other names :

alpha-2-antiplasmin; Serine (Or cysteine) peptidase inhibitor, clade F, member 2, isoform CRA_c; alpha-2-antiplasmin; serpin F2; alpha-2-AP; alpha-2-PI; OTTMUSP00000006499; OTTMUSP00000006500; alpha 2 antiplasmin; alpha-2-plasmin inhibitor; plasmin inhibitor alpha 2; pigment epithelium derived factor; serine (or cysteine) proteinase inhibitor, clade F, member 2; serine (or cysteine) peptidase inhibitor, clade F, member 2

other gene names :

Serpinf2; Serpinf2; Pli; AI747498; Serpimf2

uniprot entry name :

Q5ND36_MOUSE

clonality :

Polyclonal

host :

Goat

specificity :

This antibody is specific for alpha2AP as demonstrated by immunoelectrophoresis and ELISA.

purity :

Purified IgG. Vial containing ml of whole IgG, representing approximately 1 ml of antiserum. Total protein is 5 mg.

form :

Whole IgG, clear liquid.

concentration :

IgG concentration is mg/ml, determined by absorbance using an extinction coefficient (E1%280) of 13.4.

storage stability :

Store between -10 and -20 degree C. Product will become viscous but will not freeze. Avoid storage in frost-free freezers. Keep vial tightly capped. Allow product to warm to room temperature and gently mix before use.

app notes :

Suitable as a source of antibodies to human alpha2antiplasmin.

other info1 :

Immunogen: Human alpha2antiplasmin purified from plasma.

other info2 :

Buffer: 10 mM HEPES, pH 7.4, 150 mM NaCl, 50% (v/v) glycerol. Neutralizing Activity: Not determined

products description :

alpha2Antiplasmin (alpha2AP), also known as alpha2Plasmin Inhibitor (alpha2PI), is a member of the SERPIN family of proteinase inhibitors and the primary inhibitor of the enzyme plasmin in blood. It is produced in the liver and circulates in plasma at ~70 ug/ml (~1 uM). alpha2AP is a single chain molecule with a mass of 67 kDa as determined by SDS-PAGE. The primary target enzyme for alpha2AP is plasmin, but alpha2AP also acts as secondary or "backup" inhibitor of activated F.XI, activated Protein C and trypsin. Inhibition of these enzymes by alpha2AP occurs through proteolytic cleavage after Arg364 with subsequent rapid formation of a stable, inactive 1:1 enzyme- alpha2AP complex. alpha2AP also acts to regulate fibrinolysis by binding to the lysine binding sites on plasminogen thus competitively inhibiting plasminogen binding to fibrin. About 30% of alpha2AP present in plasma is partially degraded and lacks a peptide in the carboxyl region that contains the plasminogen-binding site. This form of alpha2AP (~65 kDa) has a reduced rate of plasmin inhibition and has been referred to as the "slow form" of alpha2AP. During fibrin formation, a portion of circulating alpha2AP is cross-linked to the alpha-chain of fibrin by activated factor XIII, and this linking of plasmin inhibitor to the plasmin substrate provides an additional measure of protection to the fibrin clot from proteolysis by plasmin1-4.

products references :

1. Aoki N, Suni Y, Miura O, Hirosawa S; Human alpha2Plasmin Inhibitor; Methods in Enzymology, 223, pp 185-197, 1993. 2. Shieh BH, Travis J; The Reactive Site of Human alpha2-Plasmin Inhibitor ; JBC 262, pp 6055-6059, 1987. 3. Moroi M, Aoki N; Isolation and Characterization of alpha2-Plasmin Inhibitor from Human Plasma; JBC 251, pp 5956-5965, 1976. 4. Harpel PC; Blood Proteolytic Enzyme Inhibitors: Their Role in Modulating Blood Coagulation and Fibrinolytic Enzyme Pathways; in Hemostasis and Thrombosis, eds. RW Colman, J Hirsh, VJ Marder and EW Salzman, pp. 738-747, J.B. Lippincott Co., Philadelphia PA, USA, 1982.

ncbi gi num :

6679383

ncbi acc num :

NP_032904.1

ncbi gb acc num :

NM_008878.2

uniprot acc num :

Q5ND36

ncbi mol weight :

54,972 Da

ncbi pathways :

Blood Clotting Cascade Pathway 198388!!Complement And Coagulation Cascades Pathway 198335!!Complement And Coagulation Cascades Pathway 83270!!Complement And Coagulation Cascades Pathway 484!!Dissolution Of Fibrin Clot Pathway 366330!!Formation Of Platelet Plug Pathway 366293!!Hemostasis Pathway 366292!!Platelet Activation Pathway 366299!!Platelet Degranulation Pathway 366320!!Response To Elevated Platelet Cytosolic Ca2+ Pathway 366318

uniprot summary :

Sequence similarities: Belongs to the serpin family. RuleBase RU000411

size :

5 mg

price :

280 USD

more info or order :

MyBioSource product webpage