Anti-Phospho-Ser503 Kv3.1, Voltage-Gated, Potassium Channel | MyBioSource MBS502105 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Phospho-Ser503 Kv3.1, Voltage-Gated, Potassium Channel

catalog :

MBS502105

quantity :

0.1 ml

price :

270 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

mouse, rat

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS502105

products type :

Antibody

products full name :

Anti-Phospho-Ser503 Kv3.1, Voltage-Gated, Potassium Channel

products short name :

Potassium Channel, Voltage-Gated, Kv3.1 Subunit (Ser503)

other names :

potassium voltage-gated channel subfamily C member 1; Potassium voltage-gated channel subfamily C member 1; potassium voltage-gated channel subfamily C member 1; NGK2; RAW2; potassium channel gene 1; voltage-gated potassium channel subunit Kv4; voltage-gated potassium channel subunit Kv3.1; potassium voltage gated channel, Shaw-related subfamily, member 1; NGK2; RAW2; Voltage-gated potassium channel subunit Kv3.1; Voltage-gated potassium channel subunit Kv4

products gene name :

KCNC1

other gene names :

Kcnc1; Kcnc1; Kv4; Kv3.1; KShIIIB; NGK2-KV4

uniprot entry name :

KCNC1_RAT

clonality :

Polyclonal

host :

Rabbit

reactivity :

Rat, mouse

sequence length :

585

specificity :

Specific for the ~100k Kv3.1 voltage-gated potassium channel protein phosphorylated at Ser503.

purity :

Affinity Purified (Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.)

form :

100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

storage stability :

For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

Quality Control: Western blots performed on each lot. WB: 1:1000. IHC (frozen sections; unpublished observations): 1:1000

other info1 :

Antigen: Phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser503 of the voltage-gated potassium channel Kv3.1, conjugated to keyhole limpet hemocyanin (KLH). Immunogen Information: Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser503 conjugated to KLH. Immunogen Species: Rat

other info2 :

Species Reactivity Note: The antibody has been directly tested for reactivity in Western blots with rat and mouse tissue. Biological Significance: Voltage-gated K+ channels are important determinants of neuronal membrane excitability. Moreover, differences in K+ channel expression patterns and densities contribute to the variations in action potential waveforms and repetitive firing patterns evident in different neuronal cell types (Maletic-Savatic et al., 1995; Pongs, 1999; Blaine and Ribera, 1998; Burger and Ribera, 1996). The Kv3.1 potassium channel is expressed at high levels in neurons that characteristically fire rapid trains of action potentials (Gan et al., 1999).Particularly high levels of this channel are found in neurons of the auditory brainstem. These neurons appear to participate in neural circuits that determine the intensity and timing of auditory stimuli and use this information to determine the location of sounds in space (von Hehn et al., 2004).

products description :

Affinity purified rabbit polyclonal antibody

products references :

Blaine JT, Ribera AB (1998) Heteromultimeric potassium channels formed by members of the Kv2 subfamily. J Neurosci 18:9585-9593. Burger C, Ribera AB (1996) Xenopus spinal neurons express Kv2 potassium channel transcripts during embryonic development. J Neurosci 16:1412-1421. Gan L, Hahn SJ, Kaczmarek LK (1999) Cell type-specific expression of the Kv3.1 gene is mediated by a negative element in the 5' untranslated region of the Kv3.1 promoter. J Neurochem 73:1350-1362. Maletic-Savatic M, Lenn NJ, Trimmer JS (1995) Differential spatiotemporal expression of K+ channel polypeptides in rat hippocampal neurons developing in situ and in vitro. J Neurosci 15:3840-3851. Pongs O (1999) Voltage-gated potassium channels: from hyperexcitability to excitement. FEBS Lett 452:31-35. von Hehn CA, Bhattacharjee A, Kaczmarek LK (2004) Loss of Kv3.1 tonotopicity and alterations in cAMP response element-binding protein signaling in central auditory neurons of hearing impaired mice. J Neurosci 24:1936-1940.

ncbi gi num :

6981122

ncbi acc num :

NP_036988.1

ncbi gb acc num :

NM_012856.1

uniprot acc num :

P25122

ncbi mol weight :

100

ncbi pathways :

Neuronal System Pathway 936410!!Potassium Channels Pathway 936467!!Voltage Gated Potassium Channels Pathway 936476

ncbi summary :

voltage gated potassium channel; functions as a delayed rectifier K+ channel [RGD, Feb 2006]

uniprot summary :

Function: This protein mediates the voltage-dependent potassium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a potassium-selective channel through which potassium ions may pass in accordance with their electrochemical gradient. Subunit structure: Heteromultimer with KCNG3, KCNG4 and KCNV2 . By similarity. Subcellular location: Membrane; Multi-pass membrane protein. Tissue specificity: Brain. Domain: The segment S4 is probably the voltage-sensor and is characterized by a series of positively charged amino acids at every third position.The tail may be important in modulation of channel activity and/or targeting of the channel to specific subcellular compartments. Sequence similarities: Belongs to the potassium channel family. C (Shaw) (TC 1.A.1.2) subfamily. Kv3.1/KCNC1 sub-subfamily. [View classification]

size :

0.1 ml

price :

270 USD

more info or order :

MyBioSource product webpage