Anti-PEBP (Phosphatidylethanolamine Binding Protein) | MyBioSource MBS502101 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-PEBP (Phosphatidylethanolamine Binding Protein)

catalog :

MBS502101

quantity :

0.1 ml

price :

235 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS502101

products type :

Antibody

products full name :

Anti-PEBP (Phosphatidylethanolamine Binding Protein)

products short name :

PEBP (phosphatidylethanolamie binding protein)

other names :

phosphatidylethanolamine-binding protein 1; Phosphatidylethanolamine-binding protein 1; phosphatidylethanolamine-binding protein 1; P23K; HCNPpp; PEBP-1; Raf-1 kinase inhibitor protein; 23 kDa morphine-binding protein; hippocampal cholinergic neurostimulating peptide; phosphatidylethanolamine binding protein 1; 23 kDa morphine-binding protein; HCNPpp; P23K

products gene name :

PEBP1

other gene names :

Pebp1; Pebp1; Pbp; HCNP; Rkip; Pbp; Pebp; PEBP-1; HCNP

uniprot entry name :

PEBP1_RAT

clonality :

Polyclonal

host :

Rabbit

reactivity :

Rat

sequence length :

187

specificity :

Specific for the ~ 22k PEBP protein in Western blots

purity :

Neat Serum

form :

100 ul neat serum

storage stability :

For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.

tested application :

Western Blot (WB)

app notes :

Quality Control: Western blots performed on each lot. WB: 1:1000

other info1 :

Antigen: Native PEBP protein purified from rat. Immunogen Information: Purified native rat PEBP. Immunogen Species: Rat

other info2 :

Species Reactivity Note: The antibody has been directly tested for reactivity in Western blot with rat tissues. Biological Significance: Phosphatidylethanolamine binding protein (PEBP), also known as Raf kinase inhibitory protein (RKIP) is a highly conserved multifunctional protein that modulates the Raf/MAPK signaling cascade and has been implicated as a suppressor of metastatic cancer (Trakul N et al., 2005). PEBP has been shown to not only inhibit cell proliferation but also to induce differentiation of human keratinocytes (Yamazaki et al., 2004). Dysregulation of calpain activity results in cellular degeneration in conditions such as Alzheimer's disease and recently PEBP has been identified as a potential in vivo calpain substrate (Chen at al., 2006).

products description :

Rabbit polyclonal antibody

products references :

Trakul N, Menard RE, Schade GR, Qian Z, Rosner MR (2005) Raf kinase inhibitory protein regulates Raf-1 but not BRaf kinase activation. J. Biol. Chem. 280(26): 24931-40. Yamazaki T, Nakano H, Hayakari M, Tanaka M, Mayama J, Tsuchida S (2004) Differentiation induction of human keratinocytes by phosphatidylethanolamine binding protein. J. Biol. Chem. 279(31):32191-95. Chen Q, Wang S, Thompson SN, Hall ED, Guttmann RP (2006) Identification and characterization of PEBP as a calpain substrate. J Neurochem. 99(4): 1133-41.

ncbi gi num :

8393910

ncbi acc num :

NP_058932.1

ncbi gb acc num :

NM_017236.1

uniprot acc num :

P31044

ncbi mol weight :

ncbi pathways :

EGFR1 Signaling Pathway 198427!!TNF-alpha NF-kB Signaling Pathway 198430

ncbi summary :

lipid binding protein; enhances acetylcholine synthesis in medial septal regions; human homolog (RKIP) has been shown to inhibit MEK- and ERK- signalling pathways [RGD, Feb 2006]

uniprot summary :

Function: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase . By similarity. Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation . By similarity.HCNP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. HCNP increases the production of choline acetyltransferase but not acetylcholinesterase. Seems to be mediated by a specific receptor. Subunit structure: Has a tendency to form dimers by disulfide cross-linking. Interacts with RAF1 and this interaction is enhanced if RAF1 is phosphorylated on residues 'Ser-338', 'Ser-339', 'Tyr-340' and 'Tyr-341'. Interacts with ALOX15; in response to IL13/interleukin-13, prevents the interaction of PEBP1 with RAF1 to activate the ERK signaling cascade . By similarity. Subcellular location: Cytoplasm. Membrane; Peripheral membrane protein. Tissue specificity: Major component of epididymal secretions and sperm plasma membranes. It is present in cytosols from a variety of other tissues. Highly expressed in brain. Miscellaneous: Seems to be associated with memory and learning disorder. Sequence similarities: Belongs to the phosphatidylethanolamine-binding protein family.

size :

0.1 ml

price :

235 USD

more info or order :

MyBioSource product webpage