antibody

Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase)

MBS502013

0.05 mL

300 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, immunohistochemistry

Antibody

Anti-CNP (2,3-cyclic nucleotide-3-phosphodiesterase)

CNP (2,3-cyclic nucleotide-3-phosphodiesterase)

2',3'-cyclic-nucleotide 3'-phosphodiesterase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; 2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNPase; 2',3'-cyclic nucleotide 3' phosphodiesterase

CNP

Cnp; Cnp; CNPF; CNPI; Cnp1; CNPII; Cnp1; CNP; CNPase

CN37_RAT

Polyclonal

Rabbit

Mouse, human, rabbit, rat and sheep

420

Specific for the ~ 46k CNP protein in Western blots

Neat serum

50 ul neat serum

For long term storage -20 degree C is recommended. Stable at -20 degree C for at least 1 year.

Western Blot (WB), Immunohistochemistry (IHC)

Quality Control: Western blots performed on each lot. WB: 1:1000. IHC: 1:1000 (formalin-fixed, Ramaswamy et al. 1990)

Antigen: Endogenous rabbit 2,3-cyclic nucleotide-3-phospho-diesterase. Immunogen Information: Endogenous rabbit 2,3 cyclic nucleotide-3-phospho-diesterase. Immunogen Species: Rabbit

Species Reactivity Note: The antibody has been directly tested for reactivity in Western blots with mouse, human, rabbit, rat and sheep tissues. Biological Significance: 2,3-cyclic nucleotide-3-phosphodiesterase (CNP) is a membrane bound, microtubule associated protein that is among the most abundant myelin proteins of the CNS. It is thought that CNP may serve as a regulator of tubulin polymerization and of microtubule distribution (Bifulco et al., 2002). It was recently found that CNP may also function as a possible linker protein anchoring microtubules to the plasma membrane via a 13 residue C-terminal CNP fragment (Bifulco et al., 2002, Esposito et al., 2008).

Rabbit polyclonal antibody

Bifulco et al. 2,3-Cyclic nucleotide 3-phosphodiesterase: a membrane bound, microtubule-associated protein and membrane anchor tubulin. PNAS 99:1807-12, 2002. Esposito C, Scrima M, Carotenuto A, Tedeschi A, Rovero P, D'Ebifulco M, D'Errico G, Malfitano AM, D'Ursi AM (2008) Structures and micelle locations of the nonlipidated and lipidated C-terminal anchor of 2,3-Cyclic nucleotide 3-phosphodiesterase. Biochemistry 47(1): 308-319.

57977323

NP_036941.1

NM_012809.2

P13233

46

microtubule-binding protein that promotes microtubule assembly and may regulate cellular distribution of microtubules [RGD, Feb 2006]

Function: May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin . By similarity. Catalytic activity: Nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. Subunit structure: Exists as monomers and homodimers . By similarity. Subcellular location: Membrane; Lipid-anchor. Melanosome . By similarity. Note: Firmly bound to membrane structures of brain white matter. Sequence similarities: Belongs to the cyclic nucleotide phosphodiesterase family. Sequence caution: The sequence AAA40939.1 differs from that shown. Reason: Frameshift at several positions. The sequence AAA40939.1 differs from that shown. Reason: Sequencing errors.

0.05 mL

300 USD