This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
antibody
product name :
Anti-Prox1
catalog :
MBS500038
quantity :
0.1 ml
price :
270 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
5G10
reactivity :
human, mouse, rat, chicken
application :
immunohistochemistry
product information
catalog number :
MBS500038
products type :
Antibody
products full name :
Anti-Prox1
products short name :
Prox1
other names :
prospero homeobox protein 1; Prospero homeobox protein 1; prospero homeobox protein 1; prospero-related homeobox 1; homeobox prospero-like protein PROX1; prospero homeobox 1; Homeobox prospero-like protein PROX1
products gene name :
PROX1
other gene names :
PROX1; PROX1; PROX-1
uniprot entry name :
PROX1_HUMAN
clonality :
Monoclonal
isotype :
IgG1
clone :
5G10
host :
Mouse
reactivity :
Chicken, human, mouse, rat
sequence length :
737
specificity :
Specifically labels prox1 in formalin-fixed, paraffin-embedded tissue.
purity :
Protein G purified (Protein G purified culture supernatant.)
form :
100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.
storage stability :
Store at -20 degree C in undiluted aliquots; stable for at least one year after date of receipt. Avoid freeze/thaw cycles.
tested application :
Immunohistochemistry (IHC)
app notes :
Quality Control: IHC performed on each lot. IHC: 1:1,000
other info1 :
Antigen: Recombinant human Prox1 protein. Immunogen Information: Recombinant human Prox1 protein. Immunogen Species: Human
other info2 :
Species Reactivity Note: The antibody has been directly tested for reactivity in human, rat, mouse and chicken. It is expected to have wide species cross reactivity. Biological Significance: Prox1 (Prospero-related homeobox 1) is a divergent homeogene that regulates cell proliferation, fate determination and differentiation during vertebrate embryonic development. The protein is expressed in the developing lens and is also detected in embryonic brain, lung, liver and kidney; while in adult it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas (Chen et al., 2006). Prox1 is thought to play a fundamental role in early development of the CNS and may regulate gene expression and development of postmitotic undifferentiated young neurons (Misra et al., 2008)
products description :
Mouse monoclonal antibody
products references :
Xiaoren Chen, Tapan P. Patel, William J. Cain, Melinda K. Duncan. Production of monoclonal antibodies against Prox1. Hybridoma (2006) Feb;25(1):27-33. Misra K, Gui H, Matise MP (2008) Prox1 regulates a transitory state for interneuron neurogenesis in the spinal cord. Dev Dyn 237(2):393-402.
ncbi gi num :
397174762
ncbi acc num :
NP_001257545.1
ncbi gb acc num :
NM_001270616.1
uniprot acc num :
Q92786
ncbi mol weight :
83,203 Da
ncbi summary :
The protein encoded by this gene is a member of the homeobox transcription factor family. Members of this family contain a homeobox domain that consists of a 60-amino acid helix-turn-helix structure that binds DNA and RNA. The protein encoded by this gene is conserved across vertebrates and may play an essential role during development. Altered levels of this protein have been reported in cancers of different organs, such as colon, brain, blood, breast, pancreas, liver and esophagus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
uniprot summary :
Function: May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons . By similarity. Subcellular location: Nucleus . Probable. Tissue specificity: Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas. Sequence similarities: Belongs to the Prospero homeobox family.Contains 1 Prospero-type homeobox DNA-binding domain. Sequence caution: The sequence CAI15309.1 differs from that shown. Reason: Erroneous gene model prediction.
size :
0.1 ml
price :
270 USD
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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