antibody

Anti-Calcitonin Gene Related Peptide (CGRP)

MBS500026

0.1 mL

345 USD

monoclonal

mouse

nonconjugated

4901

human, rat

Antibody

Anti-Calcitonin Gene Related Peptide (CGRP)

Calcitonin Gene Related Peptide (CGRP)

calcitonin gene-related peptide 1 isoform Cgrp preproprotein; Calcitonin gene-related peptide 1; calcitonin gene-related peptide 1; CGRP-I; alpha-type CGRP; calcitonin gene-related peptide I; calcitonin/calcitonin-related polypeptide, alpha; calcitonin-related polypeptide alpha; Alpha-type CGRP; Calcitonin gene-related peptide I

CALCA

Calca; Calca; CAL6; CGRP; Cal1; Calc; RATCAL6; calcitonin; Calc; CGRP-I

CALCA_RAT

Monoclonal

IgG2a

4901

Mouse

Human, rat

128

Specific for the CGRP protein in rat DRG neurons.

Protein G purified

100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western blots.

Store at -20 degree C in undiluted aliquots; stable for at least one year after date of receipt. Avoid freeze/thaw cycles.

Immunocytochemistry (ICC)

Quality Control: ICC performed on each lot. WB: not recommended. ICC: 1:50-1:100

Antigen: Rat alpha-CGRP. Immunogen Information: Purified rat alpha-CGRP. Immunogen Species: Rat

Reactivity Assumed Based on 100% Sequence Homology: Most mammals. Species Reactivity Note: The antibody has been directly tested for reactivity in rat and human. Other species have not yet been tested. It is expected that the antibody will react with most mammals. Biological Significance: Calcitonin Gene Related Peptide [CGRP] is a 37 amino acid peptide and is the most potent endogenous vasodilator currently known (Brain et al.,1985). CGRP is primarily produced in nervous tissue, however, its receptors are expressed throughout the body. CGRP is also strongly implicated in the vasodilatory effect of endogenous cannabinoid anandamide in the brain. This effect was found to be antagonized by capsazepine. CGRP is also currently a major target of research in regards to factors effecting the onset of migraine headaches (Edvinsson L., 2003). CGRP antibodies have been used successfully in immunoneutralization (Wong et al., 1993)

Mouse monoclonal antibody

Brain SD, Williams TJ, Tippins JR, Morris HR, MacIntyre I (1985) Calcitonin gene related peptide is a potent vasodilator. Nature 313 (5997): 54-6. Edvinsson L (2003) New therapeutic target in primary headaches—blocking the CGRP receptor. Expert Opin Ther Targets.7(3):377-83. Wong HC, Tache' Y, Lloud KCK, Yang H, Sternini C, Holzer P, Walsh JH (1993) Monoclonal antibody to rat alpha-CGRP: production, charactrization, and in vivo immunoneutralization activity. Hybridoma. 12:93-106.

76880482

NP_001029127.1

NM_001033955.1

P01256

13,948 Da

Amyloids Pathway (936191); Calcitonin-like Ligand Receptors Pathway (936135); Class B/2 (Secretin Family Receptors) Pathway (936134); Disease Pathway (936186); GPCR Ligand Binding Pathway (936108); Myometrial Relaxation And Contraction Pathways (198465); Signal Transduction Pathway (935956); Signaling By GPCR Pathway (936107)

an inhibitor of lactotroph function and a potent vasodilator [RGD, Feb 2006]

Function: CGRP induces vasodilation. It dilates a variety of vessels including the coronary, cerebral and systemic vasculature. Its abundance in the CNS also points toward a neurotransmitter or neuromodulator role. Subcellular location: Secreted. Sequence similarities: Belongs to the calcitonin family.

0.1 mL

345 USD