Anti-Retinoid X Receptor, beta-Isotype | MyBioSource MBS500015 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Retinoid X Receptor, beta-Isotype

catalog :

MBS500015

quantity :

0.1 ml

price :

270 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

147

reactivity :

human, mouse, rat

application :

western blot

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS500015

products type :

Antibody

products full name :

Anti-Retinoid X Receptor, beta-Isotype

products short name :

Retinoid X Receptor, b-Isotype

other names :

retinoic acid receptor RXR-beta isoform 1; Retinoic acid receptor RXR-beta; retinoic acid receptor RXR-beta; MHC class I promoter binding protein; nuclear receptor subfamily 2 group B member 2; retinoid X receptor, beta; Nuclear receptor subfamily 2 group B member 2; Retinoid X receptor beta

products gene name :

RXRB

other gene names :

RXRB; RXRB; NR2B2; DAUDI6; RCoR-1; H-2RIIBP; NR2B2

uniprot entry name :

RXRB_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

147

host :

Mouse

reactivity :

Mouse, rat

sequence length :

537

specificity :

Specific for the ~48k RXR-beta protein.

purity :

Protein G purified (Prepared from mouse ascites by ammonium sulfate precipitation followed by affinity purification on a protein G column.)

form :

100 ul in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per ml BSA and 50% glycerol. Adequate amount of material to conduct 10-mini Western Blots.

storage stability :

Store at -20 degree C; stable for at least 1 year.

tested application :

Western Blot (WB)

app notes :

Quality Control: Western blots performed on each lot. WB: 1:1000

other info1 :

Antigen: Hinge peptide corresponding to amino acids from the mouse retinoid X receptor, beta-isotype. Immunogen Information: Synthetic peptide corresponding to amino acid residues from the hinge region conjugated to KLH. Immunogen Species: Mouse

other info2 :

Species Reactivity Note: The antibody has been directly tested for reactivity in Western blots with mouse and rat tissue. Biological Significance: Retinoic acid (RA; active metabolite of vitamin A) plays a prominent role in regulating the transition of proliferating precursor cells (such as carcinoma cells and neuronal precursors) to postmitotic differentiated cells (Joshi et al., 2005). The retinoid X receptors (RXRs) family (RXRalpha, beta and gamma), preferentially bind 9-cis-RA and regulate gene transcription by forming heterodimers with a second family of RA receptors. RAs have been suggested to potentially play a therapeutic role in cervical cancer (Abu et al., 2005). RAs are known to play key roles in neuronal development and an increasing body of evidence indicates that retinoid signaling may regulate synaptic plasticity and associated learning and memory behaviors (Lane and Bailey, 2005).

products description :

Affinity purified mouse monoclonal antibody.

products references :

Abu J, Batuwangala M, Herbert K, Symonds P (2005) Retinoic acid and retinoid receptors: potential chemopreventive and therapeutic role in cervical cancer. Lancet Oncol 6:712-720. Joshi S, Guleria R, Pan J, Dipette D, Singh US (2005) Retinoic acid receptors and tissue-trans-glutaminase mediate short-term effect of retinoic acid on migration and invasion of neuroblastoma SH-SY5Y cells. Oncogene advance online publication 12 September 2005; doi: 10.1038/sj.onc.1209027. Lane MA, Bailey SJ (2005) Role of retinoid signalling in the adult brain. Prog Neurobiol 75:275-293.

ncbi gi num :

393715097

ncbi acc num :

NP_001257330.1

ncbi gb acc num :

NM_001270401.1

uniprot acc num :

P28702

ncbi mol weight :

ncbi pathways :

Adipocytokine Signaling Pathway 83093!!Adipocytokine Signaling Pathway 505!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Non-small Cell Lung Cancer Pathway 83119!!Non-small Cell Lung Cancer Pathway 531!!Nuclear Receptor Transcription Pathway 105979!!Nuclear Receptors Pathway 198848!!PPAR Signaling Pathway 83042!!PPAR Signaling Pathway 450

ncbi summary :

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). The encoded protein forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]

uniprot summary :

Function: Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5 . By similarity. Specifically binds 9-cis retinoic acid (9C-RA). Subunit structure: Homodimer . By similarity. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. Ref.1. Subcellular location: Nucleus. Tissue specificity: Expressed in a variety of tumor cell lines. Ref.10. Domain: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. Sequence similarities: Belongs to the nuclear hormone receptor family. NR2 subfamily.Contains 1 nuclear receptor DNA-binding domain. Sequence caution: The sequence BAD92481.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

size :

0.1 ml

price :

270 USD

more info or order :

MyBioSource product webpage