ELISA/assay

OX-40 (Human) ELISA

MBS494568

96 Tests

680 USD

ELISA Kit

OX-40 (Human) ELISA

OX-40

OX 40 ligand/ gp 34; Tumor necrosis factor ligand superfamily member 4; tumor necrosis factor ligand superfamily member 4; CD134 ligand; OX40 antigen ligand; glycoprotein Gp34; tax-transcriptionally activated glycoprotein 1 (34kD); tumor necrosis factor (ligand) superfamily, member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD_antigen: CD252

OX-40

TNFSF4; TNFSF4; GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TXGP1; OX40L

TNFL4_HUMAN

Human

183

2 - 8 degree C

Samples: Cell Culture Supernatant and serum

Design: Enzyme-linked immunosorbent assay. Assay Description: 2 hours (RT) + 1 hour (RT) + 10 min. (RT) = 3 hours, 10 min. total clock time.

Cytokines & Cell Signalling; Research Assays; Assay Categories

The human sCD134/OX40 ELISA is an enzyme-linked immunosorbent assay for the detection of human sCD134/OX40. For research use only, not for use in diagnostic procedures.

510294

CAA56284.1

P23510

15,427 Da

Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); TSLP Signaling Pathway (672451)

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family. Protein type: Membrane protein, integral; Cell cycle regulation; Cytokine. Chromosomal Location of Human Ortholog: 1q25. Cellular Component: extracellular space; cell surface; integral to plasma membrane. Molecular Function: cytokine activity; tumor necrosis factor receptor superfamily binding; tumor necrosis factor receptor binding; receptor binding. Biological Process: negative regulation of T-helper 1 cell differentiation; positive regulation of interleukin-12 production; negative regulation of cytokine secretion; positive regulation of T cell cytokine production; signal transduction; defense response to nematode; positive regulation of activated T cell proliferation; positive regulation of interleukin-10 production; positive regulation of interleukin-4 production; T cell proliferation; positive regulation of T-helper 2 cell differentiation; regulation of adaptive immune response; negative regulation of regulatory T cell differentiation; negative regulation of interferon-gamma production; positive regulation of cell proliferation; positive regulation of interleukin-13 production; positive regulation of memory T cell differentiation; cholesterol metabolic process; positive regulation of T-helper 2 type immune response; response to virus; negative regulation of transcription factor activity; positive regulation of immunoglobulin mediated immune response; positive regulation of interleukin-6 production; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of immunoglobulin secretion; positive regulation of interferon-gamma production; negative regulation of interleukin-17 production; positive regulation of B cell activation; regulation of inflammatory response; positive regulation of interleukin-2 production; immune response; positive regulation of alpha-beta T cell proliferation; negative regulation of transcription, DNA-dependent; acute inflammatory response; positive regulation of inflammatory response. Disease: Myocardial Infarction, Susceptibility To

96 Tests

680 USD