other

Anti-OX40L [R4930 (Oxelumab)]

MBS488212

0.2 mg

425 USD

Antibody

Anti-OX40L [R4930 (Oxelumab)]

[OX40L]

[TNFSF4; tumor necrosis factor (TNF) superfamily member 4; OX40 ligand; OX-40L; TAX transcriptionally-activated glycoprotein 1; TXGP1; gp34; CD252]

[Tumor necrosis factor ligand superfamily member 4; Tumor necrosis factor ligand superfamily member 4; tumor necrosis factor ligand superfamily member 4; tumor necrosis factor superfamily member 4; Glycoprotein Gp34; OX40 ligand; OX40L; TAX transcriptionally-activated glycoprotein 1; CD_antigen: CD252]

[OX40L]

[TNFSF4; TNFSF4; GP34; CD252; OX4OL; TXGP1; CD134L; OX-40L; TNLG2B; TXGP1; OX40L]

TNFL4_HUMAN

IgG1, Kappa

[R4930 (Oxelumab)]

Human

Human

183

Binds to human OX40L.

Protein A Affinity Purified

PBS with 0.02% Proclin 300.

1 mg/ml

Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.

Block, Flow Cytometry (FC/FACS)

This antibody binds to the co-stimulatory OX40L, inhibiting its interaction with OX40.

Immunogen: Oxelumab binds to human OX40L, the ligand of OX40, stimulatory receptor that is expressed on activated T cells, natural killer (NK) cells and natural killer T (NKT) cells.

Biosimilar; Asthma; Inflammation

121540

P23510

Cytokine Signaling In Immune System Pathway (1269310); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Immune System Pathway (1269170); TNFR2 Non-canonical NF-kB Pathway (1269329); TNFs Bind Their Physiological Receptors Pathway (1269332); Thymic Stromal LymphoPoietin (TSLP) Signaling Pathway (672451)

This gene encodes a cytokine of the tumor necrosis factor (TNF) ligand family. The encoded protein functions in T cell antigen-presenting cell (APC) interactions and mediates adhesion of activated T cells to endothelial cells. Polymorphisms in this gene have been associated with Sjogren's syndrome and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

TNFSF4: Cytokine that binds to TNFRSF4. Co-stimulates T-cell proliferation and cytokine production. Genetic variations in TNFSF4 influence susceptibility to systemic lupus erythematosus (SLE). SLE is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The upstream region of TNFSF4 contains a single risk haplotype for SLE, which is correlated with increased expression of both cell-surface TNFSF4 and TNFSF4 transcripts. Increased levels of TNFSF4 are thought to augment T-cell-APC interaction and the functional consequences of T-cell activation, thereby destabilizing peripheral tolerance. Belongs to the tumor necrosis factor family. Protein type: Cell cycle regulation; Cytokine; Membrane protein, integral. Chromosomal Location of Human Ortholog: 1q25. Cellular Component: cell surface; extracellular space; plasma membrane. Molecular Function: receptor binding; tumor necrosis factor receptor superfamily binding. Biological Process: acute inflammatory response; defense response to nematode; negative regulation of interferon-gamma production; negative regulation of interleukin-17 production; negative regulation of regulatory T cell differentiation; negative regulation of T-helper 1 cell differentiation; negative regulation of transcription factor activity; negative regulation of transcription, DNA-dependent; positive regulation of alpha-beta T cell proliferation; positive regulation of B cell activation; positive regulation of CD4-positive, alpha beta T cell differentiation; positive regulation of cell proliferation; positive regulation of immunoglobulin mediated immune response; positive regulation of immunoglobulin secretion; positive regulation of inflammatory response; positive regulation of interferon-gamma production; positive regulation of interleukin-10 production; positive regulation of interleukin-12 production; positive regulation of interleukin-13 production; positive regulation of interleukin-4 production; positive regulation of interleukin-6 production; positive regulation of memory T cell differentiation; positive regulation of T cell cytokine production; positive regulation of T cell proliferation; positive regulation of T-helper 2 cell differentiation; positive regulation of T-helper 2 type immune response; regulation of adaptive immune response; regulation of inflammatory response; response to virus; signal transduction; tumor necrosis factor-mediated signaling pathway. Disease: Myocardial Infarction, Susceptibility To

0.2 mg

425 USD