catalog number :
MBS488074
products full name :
Anti-CD200R [OX108]
products short name :
[CD200R]
products name syn :
[CD200 Cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1; CD200R1; CD200R; OX2R; CD200 receptor-like 2; HuCD200R2; CD200RLa]
other names :
[Cell surface glycoprotein CD200 receptor 1; Cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein CD200 receptor 1; CD200 receptor 1; CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1]
products gene name :
[CD200R]
other gene names :
[CD200R1; CD200R1; OX2R; MOX2R; CD200R; HCRTR2; CD200R; CRTR2; MOX2R; OX2R]
uniprot entry name :
MO2R1_HUMAN
specificity :
Recognizes human CD200R, a receptor for the CD200/OX2.
purity :
Protein A Affinity Purified
form :
PBS with (0.02% Proclin 300)
storage stability :
Store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C.
tested application :
Flow Cytometry (FC/FACS)
image1 heading :
Flow Cytometry (FC/FACS)
other info2 :
Immunogen: Recombinant protein - hCD200RCD4d3+4. Chimeric Use Statement: This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques.
products categories :
Immunology; Biotherapeuticresearch; Inflammation
products description :
Recombinant monoclonal antibody to CD200R. Manufactured using a Recombinant Platform with variable regions (i.e. specificity) from the hybridoma OX108. This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques. This chimeric rabbit antibody was made using the variable domain sequences of the original murine IgG1 format, for improved compatibility with existing reagents, assays and techniques.
products references :
Wright GJ, Cherwinski H, Foster-Cuevas M, Brooke G, Puklavec MJ, Bigler M, Song Y, Jenmalm M, Gorman D, McClanahan T, Liu MR, Brown MH, Sedgwick JD, Phillips JH, Barclay AN. Characterization of the CD200 receptor family in mice and humans and their interactions with CD200. J Immunol. 2003 Sep 15; 171(6):3034-46. PMID:12960329
ncbi pathways :
Adaptive Immune System Pathway (1269171); Immune System Pathway (1269170); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (1269201)
ncbi summary :
This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]
uniprot summary :
CD200R: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. Belongs to the CD200R family. 4 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 3q13.2. Cellular Component: external side of plasma membrane; plasma membrane; receptor complex. Molecular Function: protein binding; receptor activity. Biological Process: regulation of immune response