PKC-delta Standard | MyBioSource MBS483014 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

PKC-delta Standard

catalog :

MBS483014

quantity :

0.001 mg

price :

215 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS483014

products type :

Protein

products full name :

PKC-delta Standard

products short name :

PKC-delta

products name syn :

Protein Kinase C Delta Standard

other names :

protein kinase C delta type; Protein kinase C delta type; protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD; protein kinase C, delta; Tyrosine-protein kinase PRKCD (EC:2.7.10.2); nPKC-delta

products gene name :

PKC-delta

other gene names :

PRKCD; PRKCD; MAY1; PKCD; ALPS3; CVID9; nPKC-delta; SDK1

uniprot entry name :

KPCD_HUMAN

sequence length :

676

concentration :

20 mug/mL

storage stability :

Stable indefinitely at At -70 degree C. or at least one year at -20 degree C.

tested application :

Western Blot (WB)

app notes :

Intended for use as a standard for Western blots using enhanced chemiluminescence. For blots using less sensitive substrates, such as alkaline phosphatase, larger amounts of protein should be loaded onto the gel. Load 2 - 5 muL of standard directly from vial. No dilution is necessary.

other info2 :

Contents: 1.0 mug of protein in 50 muL. Enzyme Activity: Not enzymatically active

products description :

Description: Human recombinant kinase Cd expressed in baculoviral insect expression system. The protein is suspended in SDS/mercaptoethanol sample buffer with a bromphenol blue dye marker.

ncbi gi num :

47157325

ncbi acc num :

NP_997704.1

ncbi gb acc num :

NM_212539.1

uniprot acc num :

Q05655

ncbi mol weight :

80,953 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Alpha-synuclein Signaling Pathway (137913); Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); C-type Lectin Receptors (CLRs) Pathway (1183549); CLEC7A (Dectin-1) Signaling Pathway (1183550)

ncbi summary :

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

uniprot summary :

PKCD: an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Protein type: Protein kinase, AGC; Nuclear receptor co-regulator; Kinase, protein; Protein kinase, Ser/Thr (non-receptor); Tumor suppressor; EC 2.7.11.13; AGC group; PKC family; Delta subfamily. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; nucleus; cytosol. Molecular Function: calcium-independent protein kinase C activity; protein serine/threonine kinase activity; protein binding; protein kinase C activity; enzyme binding; metal ion binding; insulin receptor substrate binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; ATP binding. Biological Process: B cell proliferation; negative regulation of MAP kinase activity; interleukin-12 production; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; positive regulation of superoxide release; regulation of receptor activity; negative regulation of protein binding; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; platelet activation; negative regulation of peptidyl-tyrosine phosphorylation; fibroblast growth factor receptor signaling pathway; neutrophil activation; protein stabilization; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; phospholipase C activation; negative regulation of inflammatory response; defense response to bacterium; interleukin-10 production; innate immune response; gene expression; immunoglobulin mediated immune response; vascular endothelial growth factor receptor signaling pathway; blood coagulation; induction of apoptosis by oxidative stress. Disease: Autoimmune Lymphoproliferative Syndrome, Type Iii

size1 :

0.001 mg

price1 :

215 USD

more info or order :

MyBioSource product webpage