protein

Human Prothrombin

MBS480591

9 mg

500 USD

Protein

Human Prothrombin

[Prothrombin]

[prothrombin preproprotein; Prothrombin; prothrombin; prepro-coagulation factor II; prothrombin B-chain; serine protease; coagulation factor II (thrombin); Coagulation factor II]

[F2; F2; PT; THPH1; RPRGL2]

THRB_HUMAN

622

>95% by SDS-PAGE analysis.

5.3 mg/ml

Store at -70°C . Shipping: Ships on Dry Ice

Buffer: 0.02 M Tris; 0.1 M NaCI; pH 7.4

This human prothrombin is prepared from fresh frozen human plasma. Activation by Factor Va, Xa and phospholipids results in the serine protease thrombin.

4503635

NP_000497.1

NM_000506.3

P00734

72 kDa

Angiopoietin Receptor Tie2-mediated Signaling Pathway (137917); Blood Clotting Cascade Pathway (198840); Cell Surface Interactions At The Vascular Wall Pathway (106062); Class A/1 (Rhodopsin-like Receptors) Pathway (106357); Common Pathway Of Fibrin Clot Formation (106060); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); FOXA2 And FOXA3 Transcription Factor Networks Pathway (137911); Formation Of Fibrin Clot (Clotting Cascade) Pathway (106057)

Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Finally, peptides derived from the C-terminus of this protein have antimicrobial activity against E. coli and P. aeruginosa. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia. [provided by RefSeq, Nov 2014]

prothrombin: Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. Defects in F2 are the cause of factor II deficiency (FA2D). It is a very rare blood coagulation disorder characterized by mucocutaneous bleeding symptoms. The severity of the bleeding manifestations correlates with blood factor II levels. Genetic variations in F2 may be a cause of susceptibility to ischemic stroke (ISCHSTR); also known as cerebrovascular accident or cerebral infarction. A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Defects in F2 are the cause of thrombophilia due to thrombin defect (THPH1). It is a multifactorial disorder of hemostasis characterized by abnormal platelet aggregation in response to various agents and recurrent thrombi formation. A common genetic variation in the 3-prime untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increased risk of venous thrombosis. Defects in F2 are associated with susceptibility to pregnancy loss, recurrent, type 2 (RPRGL2). A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability. The term includes all miscarriages from the time of conception until 24 weeks of gestation. Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions. Belongs to the peptidase S1 family. Protein type: Secreted; Secreted, signal peptide; Apoptosis; Protease; EC 3.4.21.5. Chromosomal Location of Human Ortholog: 11p11. Cellular Component: extracellular space; Golgi lumen; endoplasmic reticulum lumen; extracellular region; plasma membrane. Molecular Function: protein binding; growth factor activity; serine-type endopeptidase activity; calcium ion binding; receptor binding. Biological Process: positive regulation of blood coagulation; multicellular organismal development; positive regulation of collagen biosynthetic process; proteolysis; regulation of cell shape; cell surface receptor linked signal transduction; negative regulation of fibrinolysis; positive regulation of cell proliferation; acute-phase response; response to wounding; negative regulation of proteolysis; platelet activation; cytosolic calcium ion homeostasis; post-translational protein modification; positive regulation of cell growth; peptidyl-glutamic acid carboxylation; positive regulation of phosphoinositide 3-kinase cascade; fibrinolysis; cellular protein metabolic process; regulation of gene expression; regulation of blood coagulation; negative regulation of astrocyte differentiation; positive regulation of protein amino acid phosphorylation; positive regulation of release of sequestered calcium ion into cytosol; blood coagulation; leukocyte migration; blood coagulation, intrinsic pathway. Disease: Thrombophilia Due To Thrombin Defect; Stroke, Ischemic; Prothrombin Deficiency, Congenital; Pregnancy Loss, Recurrent, Susceptibility To, 2

9 mg

500 USD