Anti-Human PAI-1 Monoclonal Antibody | MyBioSource MBS480274 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-Human PAI-1 Monoclonal Antibody

catalog :

MBS480274

quantity :

1 mg

price :

710 USD

clonality :

monoclonal

host :

unidentified

conjugate :

nonconjugated

clone name :

[671-3E5-29]

reactivity :

human

application :

western blot, ELISA, enzyme immunoassay

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS480274

products type :

Antibody

products full name :

Anti-Human PAI-1 Monoclonal Antibody

products short name :

[PAI-1]

products name syn :

[Anti-Human PAI-1 MoAB]

other names :

[plasminogen activator inhibitor 1; Plasminogen activator inhibitor 1; plasminogen activator inhibitor 1; endothelial plasminogen activator inhibitor; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; Endothelial plasminogen activator inhibitor; Serpin E1]

products gene name :

[PAI-1]

other gene names :

[SERPINE1; SERPINE1; PAI; PAI1; PAI-1; PLANH1; PAI1; PLANH1; PAI; PAI-1]

uniprot entry name :

PAI1_HUMAN

clonality :

Monoclonal

isotype :

IgG

clone :

[671-3E5-29]

host :

unknown

reactivity :

Human

sequence length :

402

specificity :

Human, Rabbit and Pig

purity :

Purified by Imbobilized Protein G.

concentration :

1.92 mg/mL determined spectrophotometrically.

storage stability :

Ships with Blue Ice. Upon receipt, store at -80°C.

tested application :

Western Blot (WB), ELISA (EIA)

other info1 :

Storage Buffer: 0.05 M Sodium Phosphate; 1 mM NACl; 1mM EDTA, pH 6.6. Immunogen: Recombinant full length wild-type human PAI-1.

products description :

Description: This is a non-inhibitory mouse monoclonal antibody against human plasminogen activator inhibitor-1 (PAI-1)

ncbi gi num :

10835159

ncbi acc num :

NP_000593.1

ncbi gb acc num :

NM_000602.4

uniprot acc num :

P05121

ncbi mol weight :

43 kDa non-glycosylated

ncbi pathways :

Adipogenesis Pathway (198832); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (477138); Blood Clotting Cascade Pathway (198840); Chagas Disease (American Trypanosomiasis) Pathway (147809); Chagas Disease (American Trypanosomiasis) Pathway (147795); Circadian Clock Pathway (187173); Complement And Coagulation Cascades Pathway (198880); Complement And Coagulation Cascades Pathway (83073); Complement And Coagulation Cascades Pathway (484); Direct P53 Effectors Pathway (137939)

ncbi summary :

This gene encodes a member of the serine proteinase inhibitor (serpin) superfamily. This member is the principal inhibitor of tissue plasminogen activator (tPA) and urokinase (uPA), and hence is an inhibitor of fibrinolysis. Defects in this gene are the cause of plasminogen activator inhibitor-1 deficiency (PAI-1 deficiency), and high concentrations of the gene product are associated with thrombophilia. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]

uniprot summary :

SERPINE1: a secreted protein that acts as bait for tissue plasminogen activator, urokinase, and protein C. Its rapid interaction with TPA may function as a major control point in the regulation of fibrinolysis. Belongs to the serpin family. Interacts with VTN. Binds LRP1B; binding is followed by internalization and degradation. Plasma levels of PAI-1 and VCAM-1 together may be useful in predicting post-operative recurrence in patients with colorectal cancer. Protein type: Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 7q22.1. Cellular Component: extracellular matrix; extracellular space; extracellular region; plasma membrane. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; protease binding; receptor binding. Biological Process: circadian rhythm; transcription initiation from RNA polymerase II promoter; platelet activation; extracellular matrix organization and biogenesis; positive regulation of blood coagulation; transcription, DNA-dependent; negative regulation of blood coagulation; negative regulation of smooth muscle cell migration; defense response to Gram-negative bacterium; positive regulation of receptor-mediated endocytosis; regulation of cell proliferation; positive regulation of interleukin-8 production; positive regulation of angiogenesis; fibrinolysis; platelet degranulation; negative regulation of fibrinolysis; transforming growth factor beta receptor signaling pathway; gene expression; positive regulation of transcription from RNA polymerase II promoter; regulation of receptor activity; angiogenesis; blood coagulation; chronological cell aging; negative regulation of cell adhesion mediated by integrin; negative regulation of cell migration; positive regulation of inflammatory response. Disease: Plasminogen Activator Inhibitor-1 Deficiency

size1 :

1 mg

price1 :

710 USD

more info or order :

MyBioSource product webpage