Anti-RELB Mouse mAb | MyBioSource MBS476569 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-RELB Mouse mAb

catalog :

MBS476569

quantity :

0.1 mL

price :

335 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[2E4B1]

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, FACS

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis using RELB mAb against human RELB (AA

image 2 :

Western blot analysis using RELB mAb against HEK293 (1) and RELB (AA

image 3 :

Immunofluorescence analysis of MCF-7 cells using RELB mouse mAb (green). Blue

product information

catalog number :

MBS476569

products type :

Antibody

products full name :

Anti-RELB Mouse mAb

products short name :

[RELB]

products name syn :

[IREL; I-REL; REL-B]

other names :

[RelB (plasmid); Transcription factor RelB; transcription factor RelB; RELB proto-oncogene, NF-kB subunit; I-Rel]

products gene name :

[RELB]

products gene name syn :

[IREL; I-REL; REL-B]

other gene names :

[RELB; RELB; IREL; I-REL; REL-B]

clonality :

Monoclonal

isotype :

IgG2a

clone :

[2E4B1]

host :

Mouse

reactivity :

Human

sequence length :

purity :

Unpurification

form :

Purified antibody in PBS with 0.05% sodium azide.

tested application :

Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS)

image1 heading :

Western Blot (WB)

image2 heading :

Western Blot (WB)

image3 heading :

Immunofluorescence (IF)

image4 heading :

Flow Cytometry (FC/FACS)

image4 description :

Flow cytometric analysis of MCF-7 cells using RELB mouse mAb (green) and negative control (red).

image5 heading :

Immunohistochemistry (IHC)

image5 description :

Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using RELB mouse mAb with DAB staining.

other info1 :

Immunogen: Purified recombinant fragment of human RELB (AA: 273-443) expressed in E Coli. Conjugation: Unconjugated

other info2 :

Subcellular location: Cytoplasm, Cytoskeleton, Nucleus.

products description :

Entrez Summary: NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric RelB-p50 and RelB-p52 complexes are transcriptional activators. RELB neither associates with DNA nor with RELA/p65 or REL. Stimulates promoter activity in the presence of NFKB2/p49. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment

ncbi gi num :

765526931

ncbi acc num :

AJS10497.1

ncbi mol weight :

62.1

ncbi pathways :

Alternative NF-kappaB Pathway (138004); C-type Lectin Receptors (CLRs) Pathway (1269303); CD209 (DC-SIGN) Signaling Pathway (1269309); CLEC7A (Dectin-1) Signaling Pathway (1269304); Circadian Rythm Related Genes Pathway (1458220); Cytokine Signaling In Immune System Pathway (1269310); Dectin-1 Mediated Noncanonical NF-kB Signaling Pathway (1269306); Epstein-Barr Virus Infection Pathway (585562); Epstein-Barr Virus Infection Pathway (587115); HTLV-I Infection Pathway (373901)

uniprot summary :

RELB: a transcription factor of the nuclear factor-kappaB (NFkB) transcription complex. Stimulates promoter activity in the presence NFkB1/NFkB-p50. Plays role in regulation of apoptosis in hepatocellular carcinoma through activation of downstream target genes. Does not associate with DNA or RelA/NFkB-p65. Protein type: Transcription factor. Chromosomal Location of Human Ortholog: 19q13.32. Cellular Component: cytoplasm; cytosol; nucleoplasm; nucleus. Molecular Function: chromatin binding; protein binding; transcription corepressor activity; transcription factor activity. Biological Process: circadian regulation of gene expression; I-kappaB kinase/NF-kappaB cascade; inflammatory response; innate immune response; negative regulation of interferon-beta production; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription from RNA polymerase II promoter; response to cytokine stimulus; stimulatory C-type lectin receptor signaling pathway

size1 :

0.1 mL

price1 :

335 USD

more info or order :

MyBioSource product webpage