Anti-FLT3 Mouse mAb | MyBioSource MBS476418 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-FLT3 Mouse mAb

catalog :

MBS476418

quantity :

0.1 mL

price :

335 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[7B7C3]

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis using FLT3 mAb against human FLT3 recombinant protein. (Expected MW is 32.6 kDa)

image 2 :

Immunohistochemical analysis of paraffin-embedded cervical cancer tissues using FLT3 mouse mAb with DAB staining.

image 3 :

Immunohistochemical analysis of paraffin-embedded liver cancer tissues using FLT3 mouse mAb with DAB staining.

product information

catalog number :

MBS476418

products type :

Antibody

products full name :

Anti-FLT3 Mouse mAb

products short name :

[FLT3]

products name syn :

[FLK2; STK1; CD135; FLK-2]

other names :

[FLT3 receptor tyrosine kinase; Receptor-type tyrosine-protein kinase FLT3; receptor-type tyrosine-protein kinase FLT3; fms related tyrosine kinase 3; FL cytokine receptor; Fetal liver kinase-2; FLK-2; Fms-like tyrosine kinase 3; FLT-3; Stem cell tyrosine kinase 1; STK-1; CD_antigen: CD135]

products gene name :

[FLT3]

products gene name syn :

[FLK2; STK1; CD135; FLK-2]

other gene names :

[FLT3; FLT3; FLK2; STK1; CD135; FLK-2; CD135; FLK2; STK1; FLK-2; FLT-3; STK-1]

clonality :

Monoclonal

isotype :

IgG1

clone :

[7B7C3]

host :

Mouse

reactivity :

Human

sequence length :

993

purity :

Affinity purified

form :

Purified antibody in PBS with 0.05% sodium azide

storage stability :

Store at 4°C short term. Store at -20°C long term. Avoid freeze/thaw cycle.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB : 1/500-1/2000. IHC:1/200-1/1000. ELISA: 1/10000

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

image3 heading :

Immunohistochemistry (IHC)

other info1 :

Antibody type: Primary Antibody. Conjugation: Unconjugated. Immunogen: Purified recombinant fragment of human FLT3 (AA: 930-991) expressed in E Coli. Modification: Unmodification

products description :

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

ncbi gi num :

406323

ncbi acc num :

CAA81393.1

ncbi mol weight :

130 kDa

ncbi pathways :

Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Cytokine-cytokine Receptor Interaction Pathway (83051); Cytokine-cytokine Receptor Interaction Pathway (460); Hematopoietic Cell Lineage Pathway (83078); Hematopoietic Cell Lineage Pathway (489); Pathways In Cancer (83105); Transcriptional Misregulation In Cancer Pathway (523016); Transcriptional Misregulation In Cancer Pathway (522987)

ncbi summary :

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia. [provided by RefSeq, Jan 2015]

uniprot summary :

FLT3: a receptor tyrosine kinase of the PDGFR family that binds the FL cytokine. FLT3 -/- mice have an impaired developmental capacity of primitive hematopoietic progenitor cells of all lineages with the greatest impact on lymphopoietic precursors. Activating mutations found in one third of cases of acute myeloid leukemia (AML), as well as in acute lymphoblastic leukemia, acute promyelocytic leukemia and myelodysplastic syndrome. Inhibitors: Sutent and PKC412. Protein type: EC 2.7.10.1; Kinase, protein; Membrane protein, integral; Oncoprotein; PDGFR family; Protein kinase, TK; Protein kinase, tyrosine (receptor); TK group. Chromosomal Location of Human Ortholog: 13q12.2. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: hematopoietin/interferon-class (D200-domain) cytokine receptor activity; protein binding; protein homodimerization activity; transmembrane receptor protein tyrosine kinase activity; vascular endothelial growth factor receptor activity. Biological Process: B cell differentiation; cytokine and chemokine mediated signaling pathway; hemopoiesis; leukocyte homeostasis; lymphocyte proliferation; myeloid progenitor cell differentiation; peptidyl-tyrosine phosphorylation; positive regulation of cell proliferation; positive regulation of MAP kinase activity; positive regulation of MAPKKK cascade; positive regulation of phosphoinositide 3-kinase activity; positive regulation of phosphoinositide 3-kinase cascade; positive regulation of tyrosine phosphorylation of STAT protein; pro-B cell differentiation; protein amino acid autophosphorylation; regulation of apoptosis; transmembrane receptor protein tyrosine kinase signaling pathway. Disease: Leukemia, Acute Lymphoblastic

size1 :

0.1 mL

price1 :

335 USD

more info or order :

MyBioSource product webpage