Anti-NCOR1 Mouse mAb | MyBioSource MBS475850 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-NCOR1 Mouse mAb

catalog :

MBS475850

quantity :

0.1 mL

price :

335 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot analysis using NCOR1 mouse mAb against truncated Trx-NCOR1 recombinant protein (1).

image 2 :

Immunohistochemical analysis of paraffin-embedded human cerebra (left) and breast carcinoma tissue (right), showing nuclear location with DAB staining using NCOR1 mouse mAb.

product information

catalog number :

MBS475850

products type :

Antibody

products full name :

Anti-NCOR1 Mouse mAb

products short name :

[NCOR1]

products name syn :

[N-CoR; TRAC1; hN-CoR]

other names :

[NCOR1, partial; Nuclear receptor corepressor 1; nuclear receptor corepressor 1; nuclear receptor corepressor 1]

products gene name :

[NCOR1]

products gene name syn :

[N-CoR; TRAC1; hN-CoR]

other gene names :

[NCOR1; NCOR1; N-CoR; TRAC1; N-CoR1; hN-CoR; PPP1R109; KIAA1047; N-CoR; N-CoR1]

clonality :

Monoclonal

isotype :

IgG1

host :

Mouse

reactivity :

Human

sequence length :

493

form :

Ascitic fluid containing 0.03% sodium azide.

storage stability :

Aliquot and store at -20 degree C. Avoid repeated freeze/thaw cycles.

tested application :

Western Blot (WB), Immunohistochemistry (IHC)

app notes :

WB: 1/500-1/2000. IHC: 1/200-1/1000

image1 heading :

Western Blot (WB)

image2 heading :

Immunohistochemistry (IHC)

other info1 :

Immunogen: Purified recombinant fragment of NCOR1 (aa1-192) expressed in E Coli.

other info2 :

Antibody diluents: 5% w/v nonfat dry milk, 1 x PBS, 0.1% Tween-20. Note: Centrifuge the tube 10 seconds 10,000g before opening the vial

products description :

NCOR1: Nuclear receptor co-repressor 1. This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined.

ncbi gi num :

958694685

ncbi acc num :

JAO70143.1

ncbi pathways :

Activation Of HOX Genes During Differentiation Pathway (1339139); Activation Of Anterior HOX Genes In Hindbrain Development During Early Embryogenesis Pathway (1339140); Adipogenesis Pathway (198832); Androgen Receptor Signaling Pathway (198806); BMAL1:CLOCK,NPAS2 Activates Circadian Gene Expression Pathway (1269872); C-MYB Transcription Factor Network Pathway (138073); Chromatin Modifying Enzymes Pathway (1270434); Chromatin Organization Pathway (1270433); Circadian Clock Pathway (1269871); Circadian Rythm Related Genes Pathway (1458220)

ncbi summary :

This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 17 and 20.[provided by RefSeq, Jun 2010]

uniprot summary :

N-CoR1: is a protein that regulates the activity of some transcription factors, including nuclear receptors, by promoting histone deacetylation and chromatin condensation, thereby altering the accessibility of various genes to the transcriptional machinery. Is known to play a role genetic programming including that for myogenesis. Is a component of a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid and the retinoic acid receptors in the absence of ligand. Interacts with the catalytic domain of HDAC9. Increased expression correlates with the loss of vitamin D responsiveness in aggressive androgen-independent prostate cancer cells. Its gene tends to be overexpressed in multiple-myeloma cell lines. Protein type: Nuclear receptor co-regulator; Transcription, coactivator/corepressor. Chromosomal Location of Human Ortholog: 17p12-p11.2. Cellular Component: histone deacetylase complex; membrane; nuclear chromatin; nucleoplasm; nucleus; Sin3 complex; spindle microtubule; transcriptional repressor complex. Molecular Function: histone deacetylase binding; ligand-dependent nuclear receptor binding; nuclear hormone receptor binding; protein binding; thyroid hormone receptor binding; transcription corepressor activity. Biological Process: cellular lipid metabolic process; circadian rhythm; negative regulation of JNK cascade; negative regulation of transcription from RNA polymerase II promoter; spindle assembly; transcription from RNA polymerase II promoter

size1 :

0.1 mL

price1 :

335 USD

more info or order :

MyBioSource product webpage