Anti-SHP-1 Mouse mAb | MyBioSource MBS475178 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-SHP-1 Mouse mAb

catalog :

MBS475178

quantity :

0.1 mL

price :

335 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[2B7-H7-F8]

reactivity :

human

application :

western blot, immunoprecipitation

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot detection of SHP-1 in Human tonsil, Daudi, Jurkat and Raji cell lysates using SHP-1 mouse mAb (1:1000 diluted).Predicted band size:67KDa.Observed band size:67KDa.

image 2 :

Immunoprecipitation analysis of Raji cell lysates using SHP-1 mouse mAb.

product information

catalog number :

MBS475178

products type :

Antibody

products full name :

Anti-SHP-1 Mouse mAb

products short name :

[SHP-1]

products name syn :

[HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1]

other names :

[tyrosine-protein phosphatase non-receptor type 6 isoform 1; Tyrosine-protein phosphatase non-receptor type 6; tyrosine-protein phosphatase non-receptor type 6; protein tyrosine phosphatase, non-receptor type 6; Hematopoietic cell protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1C; PTP-1C; Protein-tyrosine phosphatase SHP-1; SH-PTP1]

products gene name :

[SHP-1]

products gene name syn :

[ptpn6; HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1]

other gene names :

[PTPN6; PTPN6; HCP; HCPH; SHP1; SHP-1; HPTP1C; PTP-1C; SHP-1L; SH-PTP1; HCP; PTP1C; PTP-1C]

clonality :

Monoclonal

isotype :

IgG2a

clone :

[2B7-H7-F8]

host :

Mouse

reactivity :

Human

purity :

Affinity purified

form :

Purified mouse monoclonal antibody in PBS(pH 7.4) containing with 0.03% Proclin300 and 50% glycerol.

storage stability :

Store at +4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.

tested application :

Wetsern Blot (WB), Immunoprecipitation (IP)

app notes :

WB 1:1000

image1 heading :

Western Blot (WB)

image2 heading :

Immunoprecipitation (IP)

other info1 :

Antibody type: Primary antibody. Conjugation: Unconjugated. Modification: Unmodification. Immunogen: Purified recombinant human SHP-1 protein fragments expressed in E.coli. Target: This antibody detects endogenous levels of SHP-1 and does not cross-react with related proteins. Sequence similarity: Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily. Contains 2 SH2 domains. Contains 1 tyrosine-protein phosphatase domain. Subcellular location: Cytoplasm, Nucleus. Source: Human

products categories :

Cell Biology; Cell Cycle; Kinases/Phosphatases; Phosphatases; Signal Transduction; Signaling Pathway; G Protein Signaling; GPCR; Cancer; Cell cycle; Kinases/phosphatases; Phosphatases

products description :

Swiss-Prot Acc.P29350.Plays a key role in hematopoiesis. This PTPase activity may directly link growth factor receptors and other signaling proteins through protein-tyrosine phosphorylation. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation.

ncbi gi num :

18104989

ncbi acc num :

NP_002822.2

ncbi gb acc num :

NM_002831

uniprot acc num :

P29350

ncbi mol weight :

68kDa

ncbi pathways :

Adaptive Immune System Pathway (366160); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); B Cell Receptor Signaling Pathway (198909); B Cell Receptor Signaling Pathway (83081); B Cell Receptor Signaling Pathway (492); BCR Signaling Pathway (138058); CXCR4-mediated Signaling Events Pathway (137910); Cell Surface Interactions At The Vascular Wall Pathway (106062); Cell-Cell Communication Pathway (477132)

ncbi summary :

The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. N-terminal part of this PTP contains two tandem Src homolog (SH2) domains, which act as protein phospho-tyrosine binding domains, and mediate the interaction of this PTP with its substrates. This PTP is expressed primarily in hematopoietic cells, and functions as an important regulator of multiple signaling pathways in hematopoietic cells. This PTP has been shown to interact with, and dephosphorylate a wide spectrum of phospho-proteins involved in hematopoietic cell signaling. Multiple alternatively spliced variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]

uniprot summary :

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.

size1 :

0.1 mL

price1 :

335 USD

more info or order :

MyBioSource product webpage