PEG10 | MyBioSource MBS475079 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

PEG10

catalog :

MBS475079

quantity :

0.1 mL

price :

335 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1E2-F12-C12

reactivity :

human

application :

western blot, immunoprecipitation

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS475079

products type :

Antibody

products full name :

PEG10

products short name :

PEG10

products name syn :

AA407948; Edr; Embryonal carcinoma differentiation regulated; Embryonal carcinoma differentiation-regulated protein; HB 1; HB1; KIAA1051; Mammalian retrotransposon-derived protein 2; Mar2; Mart2; MEF3 like 1; MEF3-like protein 1; MEF3L; MEF3L1; MyEF 3; Myelin expression factor 3-like protein 1; Paternally expressed 10; Paternally expressed gene 10 ORF1; Paternally expressed gene 10 protein; Peg10; PEG10 protein; PEG10_HUMAN; Putative uncharacterized protein PEG10; Retrotransposon gag domain containing 3; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Retrotransposon-derived protein PEG10; RGAG3; Ty3/Gypsy-like protein.

other names :

retrotransposon-derived protein PEG10 isoform 2; Retrotransposon-derived protein PEG10; retrotransposon-derived protein PEG10; MEF3 like 1; embryonal carcinoma differentiation regulated; mammalian retrotransposon-derived protein 2; myelin expression factor 3-like protein 1; paternally expressed gene 10 protein; retrotransposon gag domain-containing protein 3; retrotransposon-derived gag-like polyprotein; ty3/Gypsy-like protein; paternally expressed 10; Embryonal carcinoma differentiation-regulated protein; Mammalian retrotransposon-derived protein 2; Myelin expression factor 3-like protein 1; MEF3-like protein 1; Paternally expressed gene 10 protein; Retrotransposon gag domain-containing protein 3; Retrotransposon-derived gag-like polyprotein; Ty3/Gypsy-like protein

products gene name :

PEG10

products gene name syn :

EDR; HB-1; Mar2; MEF3L; Mart2; RGAG3

other gene names :

PEG10; PEG10; EDR; HB-1; Mar2; MEF3L; Mart2; RGAG3; EDR; KIAA1051; MAR2; MART2; MEF3L1; RGAG3; MEF3-like protein 1

uniprot entry name :

PEG10_HUMAN

clonality :

Monoclonal

isotype :

IgG1

clone :

1E2-F12-C12

host :

Mouse

reactivity :

Human

sequence length :

325

purity :

Affinity Purified

concentration :

1mg/ml

tested application :

Western Blot (WB), Immunoprecipitation (IP)

app notes :

Western Blot Dilution: 1:1000

other info1 :

Research Area: Stem Cells >> Germline Stem Cells >> Spermatogonial Stem Cells. Cancer >> Oncoproteins/suppressors >> Viral proteins >> Retrovirus. Epigenetics and Nuclear Signaling >> Transcription >> Transcription Factors. Epigenetics and Nuclear Signaling. Entrez Summary: This is a paternally expressed imprinted gene that encodes transcripts containing two overlapping open reading frames (ORFs), RF1 and RF1/RF2, as well as retroviral-like slippage and pseudoknot elements, which can induce a -1 nucleotide frame-shift. ORF1 encodes a shorter isoform with a CCHC-type zinc finger motif containing a sequence characteristic of gag proteins of most retroviruses and some retrotransposons. The longer isoform is the result of -1 translational frame-shifting leading to translation of a gag/pol-like protein combining RF1 and RF2. It contains the active-site consensus sequence of the protease domain of pol proteins. Additional isoforms resulting from alternatively spliced transcript variants, as well as from use of upstream non-AUG (CUG) start codon, have been reported for this gene. Increased expression of this gene is associated with hepatocellular carcinomas. [provided by RefSeq, May 2010]. UniProt Summary: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation (By similarity). May bind to the 5'-GCCTGTCTTT-3' DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. Subunit Structure: Interacts with ALK1, SIAH1 and SIAH2.

other info2 :

Subcellular Location: Nucleus. Cytoplasm. Sequence Similarities: Contains 1 CCHC-type zinc finger. Sensitivity: This antibody detects endogenous levels of PEG10 and does not cross-react with related proteins. Immunogen: Purified recombinant human PEG10 protein fragments expressed in E Coli.

ncbi gi num :

94421473

ncbi acc num :

NP_001035242.1

ncbi gb acc num :

NM_001040152

uniprot acc num :

Q86TG7

ncbi mol weight :

ncbi pathways :

Validated Targets Of C-MYC Transcriptional Activation Pathway (169351)

ncbi summary :

This is a paternally expressed imprinted gene that is thought to have been derived from the Ty3/Gypsy family of retrotransposons. It contains two overlapping open reading frames, RF1 and RF2, and expresses two proteins: a shorter, gag-like protein (with a CCHC-type zinc finger domain) from RF1; and a longer, gag/pol-like fusion protein (with an additional aspartic protease motif) from RF1/RF2 by -1 translational frameshifting (-1 FS). While -1 FS has been observed in RNA viruses and transposons in both prokaryotes and eukaryotes, this gene represents the first example of -1 FS in a eukaryotic cellular gene. This gene is highly conserved across mammalian species and retains the heptanucleotide (GGGAAAC) and pseudoknot elements required for -1 FS. It is expressed in adult and embryonic tissues (most notably in placenta) and reported to have a role in cell proliferation, differentiation and apoptosis. Overexpression of this gene has been associated with several malignancies, such as hepatocellular carcinoma and B-cell lymphocytic leukemia. Knockout mice lacking this gene showed early embryonic lethality with placental defects, indicating the importance of this gene in embryonic development. Additional isoforms resulting from alternatively spliced transcript variants, and use of upstream non-AUG (CUG) start codon have been reported for this gene. [provided by RefSeq, Oct 2014]

uniprot summary :

PEG10: Prevents apoptosis in hepatocellular carcinoma (HCC) cells through interaction with SIAH1, a mediator of apoptosis. May also have a role in cell growth promotion and hepatoma formation. Inhibits the TGF-beta signaling by interacting with the TGF-beta receptor ALK1. When overexpressed, induces the formation of cellular extension, such as filipodia in association with ALK1. Involved at the immediate early stage of adipocyte differentiation. May bind to the 5 -GCCTGTCTTT-3 DNA sequence of the MB1 domain in the myelin basic protein (MBP) promoter. Up-regulated by MYC and dihydrotestosteron (DHT). Interacts with ALK1, SIAH1 and SIAH2. 2 isoforms of the human protein are produced by ribosomal frameshifting. Protein type: Cell development/differentiation; RNA-binding; Apoptosis; Cell cycle regulation. Chromosomal Location of Human Ortholog: 7q21. Cellular Component: cytoplasm; nucleus. Molecular Function: protein binding; DNA binding; zinc ion binding. Biological Process: apoptosis; cell differentiation; negative regulation of transforming growth factor beta receptor signaling pathway

size1 :

0.1 mL

price1 :

335 USD

more info or order :

MyBioSource product webpage