Anti-CKMT1 Mouse mAb | MyBioSource MBS475046 product information

product summary

company name :

MyBioSource

product type :

antibody

product name :

Anti-CKMT1 Mouse mAb

catalog :

MBS475046

quantity :

0.1 mL

price :

335 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

[1A6-C7-G10]

reactivity :

human, mouse

application :

western blot

more info or order :

MyBioSource product webpage

image

image 1 :

Western blot detection of CKMT1 in Mouse Colon, 293 and A431 cell lysates using CKMT1 mouse mAb (1:1000 diluted). Predicted band size: 47KDa. Observed band size: 47KDa.

product information

catalog number :

MBS475046

products type :

Antibody

products full name :

Anti-CKMT1 Mouse mAb

products short name :

[CKMT1]

products name syn :

[Acidic type mitochondrial creatine kinase; CKMT; CKMT1; CKMT1A; CKMT1B; Creatine kinase mitochondrial 1 ubiquitous; Creatine kinase U type, mitochondrial; Creatine kinase ubiquitous mitochondrial; Creatine kinase, mitochondrial 1 (ubiquitous); Creatine kinase, mitochondrial 1A; Creatine kinase, mitochondrial 1B; Mia CK; U MtCK; Ubiquitous mitochondrial creatine kinase; UMTCK]

other names :

[creatine kinase U-type, mitochondrial isoform 1; Creatine kinase U-type, mitochondrial; creatine kinase U-type, mitochondrial; creatine kinase, mitochondrial 1A; Acidic-type mitochondrial creatine kinase; Mia-CK; Ubiquitous mitochondrial creatine kinase; U-MtCK]

products gene name :

[CKMT1]

products gene name syn :

[ckmt1b; CKMT; CKMT1; UMTCK; CKMT1A]

other gene names :

[CKMT1A; CKMT1A; CKMT1; U-MtCK; mia-CK; CKMT; Mia-CK; U-MtCK]

clonality :

Monoclonal

isotype :

IgG1

clone :

[1A6-C7-G10]

host :

Mouse

reactivity :

Human, Mouse

specificity :

This antibody detects endogenous levels of CKMT1 and does not cross-react with related proteins.

purity :

Affinity Purified

form :

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol

concentration :

1mg/ml

storage stability :

Short Term: 4°C. Long Term: -20°C. Avoid freeze/thaw cycles.

tested application :

Western Blot (WB)

app notes :

WB: 1:1000

image1 heading :

Western Blot (WB)

other info1 :

Source: Human. Conjugation: Unconjugated. Modification: Unmodification. Subcellular Location: Membrane, Mitochondrion, Mitochondrion inner membrane

other info2 :

Sequence Similarity: Belongs to the ATP:guanido phosphotransferase family. Contains 1 phosphagen kinase C-terminal domain. Contains 1 phosphagen kinase N-terminal domain. Immunogen: Purified recombinant human CKMT1 protein fragments expressed in E Coli.

products categories :

Metabolism; Pathways and Processes; Metabolism processes; Apoptosis; Metabolism; Pathways and Processes; Metabolic signaling pathways; Energy transfer pathways; Energy Metabolism

products description :

Creatine kinase MT is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyume family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Creatine kinase MT occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase, this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase.

ncbi gi num :

66346730

ncbi acc num :

NP_001015001.1

ncbi gb acc num :

NM_020990.3

uniprot acc num :

P12532

ncbi mol weight :

47 kDa

ncbi pathways :

Arginine And Proline Metabolism Pathway (82957); Arginine And Proline Metabolism Pathway (323); Creatine Metabolism Pathway (106192); Creatine Pathway (413359); Creatine Pathway (468234); Metabolism Pathway (477135); Metabolism Of Amino Acids And Derivatives Pathway (106169)

ncbi summary :

Mitochondrial creatine (MtCK) kinase is responsible for the transfer of high energy phosphate from mitochondria to the cytosolic carrier, creatine. It belongs to the creatine kinase isoenzyme family. It exists as two isoenzymes, sarcomeric MtCK and ubiquitous MtCK, encoded by separate genes. Mitochondrial creatine kinase occurs in two different oligomeric forms: dimers and octamers, in contrast to the exclusively dimeric cytosolic creatine kinase isoenzymes. Many malignant cancers with poor prognosis have shown overexpression of ubiquitous mitochondrial creatine kinase; this may be related to high energy turnover and failure to eliminate cancer cells via apoptosis. Ubiquitous mitochondrial creatine kinase has 80% homology with the coding exons of sarcomeric mitochondrial creatine kinase. Two genes located near each other on chromosome 15 have been identified which encode identical mitochondrial creatine kinase proteins. [provided by RefSeq, Jul 2008]

uniprot summary :

Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.

size1 :

0.1 mL

price1 :

335 USD

more info or order :

MyBioSource product webpage