antibody

beta Actin

MBS475037

0.1 mL

335 USD

monoclonal

mouse

nonconjugated

8F10-G10

human, mouse, rat, fruit fly

Antibody

beta Actin

beta Actin

A X actin like protein; ACTB; ACTB_HUMAN; Actin; Actin cytoplasmic 1; Actx; b actin; b-actin; Beta cytoskeletal actin; Beta-actin; cytoplasmic 1; Melanoma X actin; N-terminally processed; PS1TP5 binding protein 1; PS1TP5BP1.

actin, cytoplasmic 1; Actin, cytoplasmic 1; actin, cytoplasmic 1; PS1TP5-binding protein 1; beta cytoskeletal actin; actin, beta; Beta-actin

BRWS1; PS1TP5BP1

ACTB; ACTB; BRWS1; PS1TP5BP1

ACTB_HUMAN

Monoclonal

IgG2b

8F10-G10

Mouse

Human, Mouse, Monkey, Guinea Pig, Rat, Hamster, S.cerevisiae, Arabidopsis, Pichia pastoris, Rabbit, Z, D.melanogaster, leaf of rice, fruit of cucumber, chlamydomonas.

375

Affinity Purified

1mg/ml

Western Blot (WB)

Western Blot Dilution: 1:10000

Research Area: Signal Transduction >> Cytoskeleton / ECM >> Cytoskeleton >> Microfilaments >> Actin etc >> Actin. Tags & Cell Markers >> Subcellular Markers >> Cytoskeleton >> Actin. Isotype/Loading Controls >> Loading Controls >> beta actin. Entrez Summary: This gene encodes one of six different actin proteins.Actins are highly conserved proteins that are involved in cell motility,structure,and integrity.This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins.[provided by RefSeq,Jul 2008]. UniProt Summary: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Subunit Structure: Polymerization of globular actin(G-actin)leads to a structural filament(F-actin)in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the BAF complex, which includes at least actin(ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCSAM.

Subcellular Location: Cytoplasm > cytoskeleton. Sequence Similarities: Belongs to the actin family. Sensitivity: This antibody detects endogenous levels of beta actin and does not cross-react with related proteins. Immunogen: Purified recombinant human beta actin protein fragments expressed in E Coli.

4501885

NP_001092.1

NM_001101

P60709

45

Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Arrhythmogenic Right Ventricular Cardiomyopathy Pathway (672454); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (117293); Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) Pathway (116129); Axon Guidance Pathway (105688); Bacterial Invasion Of Epithelial Cells Pathway (149807); Bacterial Invasion Of Epithelial Cells Pathway (148661); Chaperonin-mediated Protein Folding Pathway (106242); Chromatin Modifying Enzymes Pathway (1127682)

This gene encodes one of six different actin proteins. Actins are highly conserved proteins that are involved in cell motility, structure, and integrity. This actin is a major constituent of the contractile apparatus and one of the two nonmuscle cytoskeletal actins. [provided by RefSeq, Jul 2008]

ACTB: Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Each actin can bind to 4 others. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Component of the BAF complex, which includes at least actin (ACTB), ARID1A, ARID1B/BAF250, SMARCA2, SMARCA4/BRG1, ACTL6A/BAF53, ACTL6B/BAF53B, SMARCE1/BAF57 SMARCC1/BAF155, SMARCC2/BAF170, SMARCB1/SNF5/INI1, and one or more of SMARCD1/BAF60A, SMARCD2/BAF60B, or SMARCD3/BAF60C. In muscle cells, the BAF complex also contains DPF3. Found in a complex with XPO6, Ran, ACTB and PFN1. Component of the MLL5-L complex, at least composed of MLL5, STK38, PPP1CA, PPP1CB, PPP1CC, HCFC1, ACTB and OGT. Interacts with XPO6 and EMD. Interacts with ERBB2. Interacts with GCET2. Belongs to the actin family. Protein type: Motility/polarity/chemotaxis; Cytoskeletal. Chromosomal Location of Human Ortholog: 7p22. Cellular Component: cortical cytoskeleton; extracellular space; NuA4 histone acetyltransferase complex; protein complex; focal adhesion; postsynaptic density; cytosol; ribonucleoprotein complex; nucleoplasm; cytoskeleton; membrane; axon; cytoplasm; nuclear chromatin; plasma membrane. Molecular Function: protein binding; nucleosomal DNA binding; structural constituent of cytoskeleton; Tat protein binding; kinesin binding; nitric-oxide synthase binding; protein kinase binding; ATP binding. Biological Process: intercellular junction assembly and maintenance; axon guidance; establishment and/or maintenance of chromatin architecture; protein folding; retinal homeostasis; de novo posttranslational protein folding; cellular protein metabolic process; substantia nigra development; ATP-dependent chromatin remodeling; ephrin receptor signaling pathway; innate immune response; blood coagulation; cell motility; vascular endothelial growth factor receptor signaling pathway. Disease: Dystonia, Juvenile-onset; Baraitser-winter Syndrome 1

0.1 mL

335 USD