antibody

Anti-TIF1gamma/TRIM33 Mouse mAb

MBS475035

0.1 mL

335 USD

monoclonal

mouse

nonconjugated

[3H7-C8-B9]

Antibody

Anti-TIF1gamma/TRIM33 Mouse mAb

[TIF1gamma/TRIM33]

[8030451N04Rik; AI413936; cb1085; DKFZp586K1123; E3 ubiquitin-protein ligase TRIM33; EC 6.3.2.-; Ectodermin; Ectodermin homolog; FLJ11429; FLJ32925; id:ibd2175; MGC136680; mKIAA1113; OTTHUMP00000013662; OTTHUMP00000013663; Protein Rfg7; PTC7; Ret fused gene 7; RET-fused gene 7 protein; RFG7; Rfg7 protein; TF1G; TIF1-gamma; TIF1G; TIF1GAMMA; TIFGAMMA; Transcription intermediary factor 1-gamma; Transcriptional intermediary factor 1 gamma; TRI33_HUMAN; Trim33; Tripartite motif containing 33; Tripartite motif containing 33 protein; tripartite motif-containing 33; Tripartite motif-containing protein 33; wu:fc17f10; zgc:136680]

[E3 ubiquitin-protein ligase TRIM33 isoform alpha; E3 ubiquitin-protein ligase TRIM33; E3 ubiquitin-protein ligase TRIM33; tripartite motif containing 33; Ectodermin homolog; RET-fused gene 7 protein; Protein Rfg7; RING-type E3 ubiquitin transferase TRIM33Curated; Transcription intermediary factor 1-gamma; TIF1-gamma; Tripartite motif-containing protein 33]

[TIF1gamma/TRIM33]

[trim33; ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA]

[TRIM33; TRIM33; ECTO; PTC7; RFG7; TF1G; TIF1G; TIFGAMMA; TIF1GAMMA; KIAA1113; RFG7; TIF1G; Protein Rfg7; TIF1-gamma]

Monoclonal

IgG2a

[3H7-C8-B9]

Mouse

Human

1127

Affinity Purified

Purified mouse monoclonal in buffer containing 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%, glycerol

0.5mg/ml

Store at +4°C short term. Store at -20°C long term. Avoid freeze/thaw cycle.

Western Blot (WB)

WB: 1:1000

Western Blot (WB)

Source: Human. Modification: Unmodification. Conjugation: UnconJugated. Antibody type: Primary antibody. Immunogen: Purified recombinant human TIF1 gamma / TRIM33 protein fragments expressed in E Coli. Sensitivity: This antibody detects endogenous levels of TIF1 gamma / TRIM33 and does not cross-react with related proteins. Sequence Similarities: Belongs to the TRIMiRBCC family._xOOOD_ Contains 2 B box-type zinc fingers.JOOOD_ Contains 1 bromo domain._xOOOD_ Contains 1 PHD-type zinc finger._xOOOD_ Contains 1 RING-type zinc finger

Subunit Structure: Homooligomer and heterooligomer with TRIM24 and TRIM28 family members. Interacts with SMAD4 in unstimulated cells. Found in a complex with SMAD2 and SMAD3 upon addition of TGF-beta. Interacts with SMAD2 and SMAD3. Interacts with SMAD4 under basal and induced conditions and, upon TGF-beta signaling, with activated SMAD2. Forms a ternary complex with SMAD4 and SMAD2 upon TGF-beta signaling. Subcellular Location: Nucleus

Epigenetics and Nuclear Signaling; Transcription; Co-factors; Stem Cells; Hematopoietic Progenitors; Intracellular Molecules; Stem Cells; Signaling Pathways; TGF beta; Nuclear

Entrez Summary: The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.

74027249

NP_056990.3

NM_015906

Q9UPN9

140kDa

Disease Pathway (530764); Downregulation Of SMAD2/3:SMAD4 Transcriptional Activity Pathway (645266); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Loss Of Function Of SMAD2/3 In Cancer Pathway (906019); Loss Of Function Of SMAD4 In Cancer Pathway (906017); Loss Of Function Of TGFBR1 In Cancer Pathway (906025); Loss Of Function Of TGFBR2 In Cancer Pathway (906022); SMAD2/3 MH2 Domain Mutants In Cancer Pathway (906021); SMAD2/3 Phosphorylation Motif Mutants In Cancer Pathway (906020)

The protein encoded by this gene is thought to be a transcriptional corepressor. However, molecules that interact with this protein have not yet been identified. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined. [provided by RefSeq, Jul 2008]

TIF1G: an atypical protein kinase that functions as a transcriptional repressor. Translocation with RET generates the TRIM33/RET (PTC7) oncogene. The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. Two splice variant isoforms have been described. Protein type: ATYPICAL group; EC 6.3.2.-; EC 6.3.2.19; Kinase, protein; Ligase; Protein kinase, atypical; TIF1 family; Transcription, coactivator/corepressor; Ubiquitin conjugating system; Ubiquitin ligase. Chromosomal Location of Human Ortholog: 1p13.2. Cellular Component: intracellular membrane-bound organelle; nucleoplasm; nucleus. Molecular Function: protein binding; ubiquitin-protein ligase activity. Biological Process: negative regulation of BMP signaling pathway; negative regulation of transcription from RNA polymerase II promoter; protein ubiquitination; regulation of transforming growth factor beta receptor signaling pathway. Disease: Thyroid Carcinoma, Papillary

0.1 mL

335 USD