protein

Semaphorin-3A (C-terminal) Peptide

MBS474062

0.05 mg

130 USD

Peptide

Semaphorin-3A (C-terminal) Peptide

Semaphorin-3A (C-terminal) Peptide

semaphorin-3A; Semaphorin-3A; semaphorin-3A; collapsin 1; semaphorin D; semaphorin L; semaphorin III; OTTHUMP00000161379; OTTHUMP00000208884; sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A; Semaphorin III

SEMA3A; SEMA3A; SemD; SEMA1; SEMAD; SEMAL; coll-1; Hsema-I; SEMAIII; Hsema-III; MGC133243; SEMAD

SEM3A_HUMAN

771

Peptide Sequence: Semaphorin 3A synthetic peptide corresponding to amino acids in the Cterminal region of human Sema3A. This sequence has two amino acid differences from rat and mouse Sema3A, and has low homology to other semaphorin family members.

The peptide is specifically recognized by anti-Sema3A (C-terminal) antibody (SP1241) in ELISA, and has been shown to block the reactivity of SP1241 during Western blot. In addition, the peptide is recommended for use in blocking SP1241 reactivity in immunocytochemistry.

Blocking Peptide is supplied in 50ul phosphate-buffered saline and 0.05% sodium azide.

Store at -20 degree C. Stable for 1 year.

Blocking: 1:1,000. ELISA: 50 ng/well

One family of inhibitory axon guidance molecules is the semaphorins. The semaphorins include secreted, transmembrane, and GPIanchored extracellular molecules that are involved in regulating axon guidance by inhibiting axons from growing toward incorrect targets. Semaphorin 3A (Sema3A) may play a particularly interesting role in limiting axon regeneration since it is expressed in meningeal fibroblasts that invade the injured spinal cord and surround the glial scar. In addition, the Sema3A co-receptors, Neuropilin -1 and Plexin-A1, are expressed on axons that regenerate up to the injured region, but do not cross this Sema3A-containing region. Thus, Sema3A and its co-receptors may have important roles in regulating axon guidance during neuronal development and after neuronal injury.

Kolodokin, A.L. et al. (1993) Cell 75:1389. Luo, Y. et al. (1993) Cell 75:217. Pasterkamp, R.J. & Verhaagen, J. (2001) Brain Res Rev 35:36.

5174673

NP_006071.1

NM_006080.2

Q14563

86487 Da

Axon Guidance Pathway (83065); Axon Guidance Pathway (476); Axon Guidance Pathway (105688); CRMPs In Sema3A Signaling Pathway (119525); SEMA3A-Plexin Repulsion Signaling By Inhibiting Integrin Adhesion Pathway (119523); Sema3A PAK Dependent Axon Repulsion Pathway (119524); Semaphorin Interactions Pathway (119519)

This gene is a member of the semaphorin family and encodes a protein with an Ig-like C2-type (immunoglobulin-like) domain, a PSI domain and a Sema domain. This secreted protein can function as either a chemorepulsive agent, inhibiting axonal outgrowth, or as a chemoattractive agent, stimulating the growth of apical dendrites. In both cases, the protein is vital for normal neuronal pattern development. Increased expression of this protein is associated with schizophrenia and is seen in a variety of human tumor cell lines. Also, aberrant release of this protein is associated with the progression of Alzheimer's disease. [provided by RefSeq]

Function: Induces the collapse and paralysis of neuronal growth cones. Could serve as a ligand that guides specific growth cones by a motility-inhibiting mechanism. Binds to the complex neuropilin-1/plexin-1. Subcellular location: Secreted. Domain: Strong binding to neuropilin is mediated by the carboxy third of the protein. Sequence similarities: Belongs to the semaphorin family.Contains 1 Ig-like C2-type (immunoglobulin-like) domain.Contains 1 PSI domain.Contains 1 Sema domain.

0.05 mg

130 USD