product summary
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company name :
MyBioSource
product type :
protein
product name :
phospho-Cofilin 1 (Ser-3) Blocking Peptide
catalog :
MBS474028
quantity :
0.05 mg
price :
130 USD
more info or order :
product information
catalog number :
MBS474028
products type :
Peptide
products full name :
phospho-Cofilin 1 (Ser-3) Blocking Peptide
products short name :
phospho-Cofilin 1 (Ser-3) Peptide
products name syn :
phospho-Cofilin 1 (Ser-3) Peptide
sequence :
Peptide Sequence: Phospho-Cofilin 1 (Ser-3) synthetic peptide corresponds to amino acid residues around serine 3 of human Cofilin 1. This peptide sequence has 100% homology with similar regions of rat and mouse Cofilin 1, and has two amino acid differences from human Cofilin 2.
specificity :
The peptide is specifically recognized by Cofilin 1 (Ser-3) phospho-specific antibody (CP1151) in ELISA, and has been shown to block the reactivity of CP1151 during Western blot. In addition, the peptide is recommended for use in blocking CP1151 reactivity in immunocytochemistry.
form :
Blocking Peptide is supplied in 50ul phosphate-buffered saline and 0.05% sodium azide.
storage stability :
Store at -20 degree C. Stable for 1 year.
app notes :
Antibody Blocking: 1: 1000. ELISA: 50 ng/well
products description :
Members of the ADF/cofilin (AC) family are actin-severing proteins that regulate actin remodeling during cellular events such as cell migration, cytokinesis, phagocytosis, endocytosis, axon development, and immune cell activation. In mammals, there are three members of the AC family, muscle-specific cofilin (Cofilin 2), non-muscle cofilin (Cofilin 1), and ADF. In humans, cofilin 1 and ADF have 72% identity, with the major amino acid differences found in the C-terminal region. Regulation of cofilin activity can occur through serine phosphorylation. Activation of cofilin kinases, LIMK1 or LIMK2, leads to phosphorylation of cofilin at serine 3. This phosphorylation disrupts cofilin binding to actin in vitro and in vivo. Multiple phosphatases, PP1, PP2A, PP2B, slingshot, and chronophin can dephosphorylate Ser-3 and activate actin binding. Thus, Ser-3 phosphorylation is a major site for the regulation of cofilin activity.
products references :
Bamburg, J.R. (1999). Annu Rev Cell Dev Biol. 15:185. Maciver, S.K. & Hussey, P.J. (2002). Genome Biol. 3(5): 3007
size1 :
0.05 mg
price1 :
130 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
"MyBioSource offers the best products at unbeatable prices."
Please spend a few minutes to browse our online catalogs and see the wide range of products available. We ship our products through our shipping/distribution facility in San Diego, California, USA.
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