product summary
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company name :
MyBioSource
product type :
protein
product name :
Unphosphorylated beta-III-Tubulin (Ser-444) Peptide
catalog :
MBS474003
quantity :
0.05 mg
price :
130 USD
more info or order :
product information
catalog number :
MBS474003
products type :
Peptide
products full name :
Unphosphorylated beta-III-Tubulin (Ser-444) Peptide
products short name :
beta-III-Tubulin (Ser-444) Peptide
products name syn :
Unphosphorylated bIII-Tubulin (Ser-444) Peptide
sequence :
Peptide Sequence: Unphosphorylated beta-III-Tubulin (Ser-444) synthetic peptide contains amino acid residues around serine 444 of human beta-III-tubulin. This sequence is not found in beta-I or beta-II-tubulin isotypes, but is well conserved in beta-III-tubulins from rat and mouse.
specificity :
The peptide is specifically recognized by unphosphorylated beta III-Tubulin (Ser-444) antibody (TP1811) in ELISA, and has been shown to block the reactivity of TP1811 in Western blot and immunocytochemistry.
form :
Blocking Peptide is supplied in 50ul phosphate-buffered saline and 0.05% sodium azide.
storage stability :
Store at -20 degree C. Stable for 1 year.
app notes :
Blocking: 1:1,000. ELISA: 50 ng/well
products description :
Microtubules (MTs) are cytoskeletal elements that play an essential role in cell division and cytoplasmic organization. MTs are dynamic polymers of alpha/beta-tubulin heterodimers. At least two populations of MTs, called dynamic and stable according to their rates of turnover, are readily distinguishable in cells. The proteins associated with MTs (MAPs) are among the bestknown factors that regulate MT dynamics and stability. In addition, a variety of different post-translational modifications may also regulate MT dynamics and stability. Phosphorylation is one of these modifications and it can occur on serine, threonine, and tyrosine residues in beta-tubulin isoforms. Multiple kinases can phosphorylate Ser-444 at the C-terminus of beta-III-tubulin in vitro. Unphosphorylated Ser-444 in beta-III-tubulin is an early marker for cells of neuronal lineage, while phosphorylation of Ser-444 is upregulated after neuronal maturation and may preferentially occur in assembled MTs. By contrast, Cdk1 phosphorylation of Ser-172 in beta-tubulin occurs in mitotic cells and may impair tubulin incorporation into microtubules.
products references :
Fourest-Lieuvin, A. et al. (2006) Mol. Biol. Cell. 17(3):1041. Westermann, S. & Weber, K. (2003) Nat. Rev. Mol. Cell. Biol. 4:938. Fanarraga, M.L. et al. (1999) Eur. J. Neurosci. 11:517. Diaz-Nido, J. et al. (1990) J Biol. Chem. 265(23):13949.
size1 :
0.05 mg
price1 :
130 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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