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company name :
MyBioSource
product type :
antibody
product name :
SHP1 (Ser-591), phospho-specific
catalog :
MBS472061
quantity :
0.1 mL
price :
380 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
antigen modification :
phosphorylated
application :
western blot, ELISA
more info or order :
product information
catalog number :
MBS472061
products type :
Antibody
products full name :
SHP1 (Ser-591), phospho-specific
products short name :
SHP1 (Ser-591)
products name syn :
PTP-1C; Protein-tyrosine phosphatase 1C; SH-PTP1; SHP-1
clonality :
Polyclonal
host :
Rabbit
reactivity :
Human, Rat, Mouse
specificity :
This antibody was cross-adsorbed to a non-specific phospho-serine peptide then affinity-purified using phospho-SHP1 (Ser-591) peptide. The antibody detects a 68 kDa* band on SDS-PAGE immunoblots of human Jurkat and A431 cells treated with pervanadate, as wellas A431 cells treated with EGF.
purity :
Affinity Purified
form :
Rabbit polyclonal, affinity-purified antibody is supplied in 100 ul phosphate-buffered saline, 50% glycerol, 1 mg/ml BSA, and 0.05% sodium azide.
storage stability :
Store at -20 degree C. Do not aliquot. Stable for 1 year.
tested application :
ELISA, Western Blot
app notes :
ELISA: 1:2000. Western Blot: 1:1000
other info1 :
Immunogen: Phospho-SHP1 (Ser-591) synthetic peptide (coupled to carrier protein) corresponding to amino acids around serine 591 in human SHP1. The
sequence is highly conserved in rat and mouse SHP1.
products description :
SHP1 (PTP1C, SH-PTP1, or HCP) is a protein-tyrosine phosphatase (PTP) involved in cell migration, cell proliferation, and immune cell function. This phosphatase contains two N-terminal SH2 domains and a C-terminal phosphatase domain. SHP1 associates with a variety of cytokine and growth factor receptors and regulates signal transduction through dephosphorylation of these receptors or their downstream effectors. Downstream of receptor activation, SHP1 regulates the transcriptional activity stimulated by JAK/Stat and MAPK pathways. SHP1 activity is regulated by both tyrosine and serine phosphorylation. Phosphorylation of Tyr-536 and Tyr-564 stimulates phosphatase activity and promotes interaction with Grb-2. Serine phosphorylation at Ser-591 is mediated by PKC-alpha and leads to inhibition of phosphatase activity. Thus, phosphorylation at tyrosine relative to serine residues may be regulated by different cell signaling pathways to control SHP1 activity.
products references :
Jones, M.L. et al. (2004) J. Biol. Chem. 279(39):40475. Zhang, Z. et al. (2003) J. Biol. Chem. 278(7):4668. Zhang, J. et al. (2000) Semin. Immunol. 12:361. Simoneau, M. et al. (2008) J Biol Chem Epub:July 10. (WB: S591A transfectants)
size1 :
0.1 mL
price1 :
380 USD
more info or order :
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.
"MyBioSource's number 1 vision is to be the world's number 1 quality reagents provider."
Our goal is to provide researchers, scientists and customers alike with a one-stop-shop for all of their reagents needs, whether it is monoclonal antibody, polyclonal antibody, recombinant protein, peptide, etc...
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